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Invitrogen

Phospho-Estrogen Receptor alpha (Tyr537) Monoclonal Antibody (M545)

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产品信息

MA5-47625

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

M545

抗原

Clone M545 was generated from a phospho-ERalpha (Tyr-537) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding Tyr-537 in human ERalpha. This sequence is well conserved in rat and mouse ERalpha, and is also well conserved in ERbeta (Tyr-488).

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA, 50% glycerol

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2942606

产品详细信息

This antibody detects several forms of ERalpha ranging from 66 to 35 kDa* on SDS-PAGE immunoblots of MCF-7 cells treated with pervanadate, and this reactivity is removed after alkaline phosphatase treatment.

靶标信息

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: DKFZp686N23123; E2 receptor alpha; ER; Er alpha; ER delta E7 isoform; ER-alpha; ER-alpha; del.3*,+1*,4,5,6,7* variant; ER-alpha; del.3*,4,5,6,7*/770 variant; ER-alpha; del.3*,4,5,6,7,8*/862 variant; ER-alpha; del.4*,5*,7 variant; ER-alpha; del.4*,5,6*/548 variant; ER-alpha; del.4*,5,6,7*/714 variant; ER-alpha; del.4*,5,6,7,8*/754 variant; ER-alpha; estrogen receptor alpha delta 3*,4,5,6,7*/819 cingulate gyrus isoform; ER-alpha; estrogen receptor alpha delta 3*,4,5,6,7*/833 superior frontal gyrus isoform; ER-alpha; estrogen receptor alpha delta 4*,5,6,7*/747 substantia nigra isoform; ER36; esr 1; esr-1; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1 (alpha); estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor-related protein; hER-alpha36; lacks a part of the exon 3, exons 4-6, and part of exon 7; contains an 822 base in frame deletion; lacks most of the exon 3, exons 4-7, and part of exon 8; lacks most of the exon 4, exons 5-6, and part of exon 7; lacks the end of the exon 3, exons 4-7, and part of exon 8; MB1; Nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha; receptor; RP1-130E4.1; steroid hormone receptor; unnamed protein product

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基因别名: ER; ER-alpha; ERa; ERalpha; ESR; ESR1; ESRA; Estr; Estra; ESTRR; NR3A1; RNESTROR

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UniProt ID: (Human) P03372, (Mouse) P19785, (Rat) P06211

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Entrez Gene ID: (Human) 2099, (Mouse) 13982, (Rat) 24890

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding TFIIB-class transcription factor binding transcription cofactor binding transcription corepressor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding protein binding calmodulin binding beta-catenin binding zinc ion binding lipid binding TBP-class protein binding enzyme binding protein kinase binding nitric-oxide synthase regulator activity estrogen receptor activity estrogen receptor binding estrogen response element binding identical protein binding sequence-specific DNA binding metal ion binding ATPase binding 14-3-3 protein binding sequence-specific double-stranded DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor binding type 1 metabotropic glutamate receptor binding protein complex binding RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding hormone binding
参与通路
negative regulation of transcription from RNA polymerase II promoter antral ovarian follicle growth epithelial cell development chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter signal transduction phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration androgen metabolic process male gonad development negative regulation of gene expression intracellular steroid hormone receptor signaling pathway intracellular estrogen receptor signaling pathway response to estradiol regulation of toll-like receptor signaling pathway negative regulation of smooth muscle cell apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity response to estrogen positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter fibroblast proliferation positive regulation of fibroblast proliferation stem cell differentiation regulation of inflammatory response positive regulation of nitric-oxide synthase activity positive regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II transcriptional preinitiation complex assembly uterus development vagina development prostate epithelial cord elongation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis regulation of branching involved in prostate gland morphogenesis mammary gland branching involved in pregnancy mammary gland alveolus development epithelial cell proliferation involved in mammary gland duct elongation protein localization to chromatin cellular response to estrogen stimulus cellular response to estradiol stimulus cellular response to oxygen-containing compound negative regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of epithelial cell apoptotic process osteoblast development transcription, DNA-templated positive regulation of phospholipase C activity intracellular receptor signaling pathway regulation of apoptotic process regulation of neuron apoptotic process positive regulation of epidermal growth factor receptor signaling pathway negative regulation of glucose import decidualization positive regulation of retinoic acid receptor signaling pathway negative regulation of smooth muscle cell proliferation Sertoli cell development Sertoli cell proliferation positive regulation of ERK1 and ERK2 cascade negative regulation of triglyceride metabolic process negative regulation of neuron death baculum development
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