Invitrogen

Phospho-FGFR3 (Tyr724) Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
Phospho-FGFR3 (Tyr724) Polyclonal Antibody

产品信息

PA5-106142

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human FGFR3(Accession P22607), corresponding to amino acid residues around phosphorylated Tyr724.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2817540

产品详细信息

Antibody detects endogenous levels of FGFR3 only when phosphorylated at Tyr724.

靶标信息

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD333; FGF Receptor; FGFR; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; tyrosine kinase JTK4

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基因别名: ACH; CD333; CEK2; Fgfr-3; FGFR3; Flg-2; FR3; HBGFR; HSFGFR3EX; JTK4; Mfr3; sam3

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UniProt ID: (Human) P22607

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Entrez Gene ID: (Human) 2261, (Rat) 84489, (Mouse) 14184

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功能
protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity growth factor activity nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
参与通路
MAPK cascade skeletal system development endochondral ossification chondrocyte differentiation endochondral bone growth JAK-STAT cascade cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of phospholipase activity regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation bone mineralization chondrocyte proliferation phosphatidylinositol-3-phosphate biosynthetic process positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of MAPK cascade positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling negative regulation of developmental growth bone morphogenesis positive regulation of ERK1 and ERK2 cascade bone maturation fibroblast growth factor receptor apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter positive regulation of endothelial cell proliferation morphogenesis of an epithelium lens morphogenesis in camera-type eye negative regulation of cell proliferation oligodendrocyte development substantia nigra development central nervous system myelination cell differentiation forebrain development positive regulation of protein ubiquitination somatic stem cell population maintenance post-anal tail morphogenesis positive regulation of neuron apoptotic process positive regulation of cell differentiation negative regulation of mitotic nuclear division negative regulation of smoothened signaling pathway digestive tract morphogenesis response to axon injury negative regulation of astrocyte differentiation inner ear development negative regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation cartilage development inner ear receptor cell differentiation axonogenesis involved in innervation alveolar secondary septum development lens fiber cell development epithelial cell fate commitment positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway cochlea development positive regulation of canonical Wnt signaling pathway protein phosphorylation apoptotic process phosphorylation
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