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Invitrogen

Phospho-FLNA/FLNB (Ser2152, Ser2107) Recombinant Rabbit Monoclonal Antibody (K01_2K92)

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产品信息

MA567869

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:100
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-
产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_2K92

抗原

A synthetic phosphopeptide corresponding to residues surrounding Ser2152 of human Filamin A.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA

内含物

0.01% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

FLNA and FLNB encode filamin A and filamin B, large actin binding scaffold proteins that crosslink F actin into orthogonal networks and anchor signaling receptors and ion channels to the cytoskeleton. Each filamin forms a dimer through a C terminal domain and contains an N terminal actin binding module followed by multiple immunoglobulin like repeats that provide mechanical flexibility and sites for interaction with membrane proteins, small GTPases, kinases, and transcriptional regulators. FLNA is broadly expressed and crucial for cell migration, mechanosensing, platelet function, and neuronal development, whereas FLNB has prominent roles in skeletal patterning, chondrocyte differentiation, and tissue morphogenesis. Pathogenic variants in FLNA cause periventricular nodular heterotopia, cardiovascular anomalies, and platelet disorders, while FLNB mutations lead to skeletal dysplasias such as atelosteogenesis and boomerang dysplasia, highlighting nonredundant functions despite overlapping activities. Filamins serve as mechanotransducers that couple extracellular matrix forces to intracellular signaling and gene expression, and they are studied using actin dynamics assays, interaction proteomics, imaging of cytoskeletal architecture, and genetic perturbation in cellular and animal models.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ABP-278; ABP-280; ABP-280 homolog; actin binding protein 278; actin binding protein 280; Actin-binding protein 280; Actin-binding-like protein; Alpha-filamin; Beta-filamin; Endothelial actin-binding protein; Endothelial actin-binding protein 280); epididymis secretory sperm binding protein; Fh1; Filamin A; filamin A, alpha; Filamin B; filamin B, beta; Filamin homolog 1; filamin, alpha; filamin, beta; Filamin-1; Filamin-3; Filamin-A; Filamin-B; FLN-A; FLN-B; FLN1; FLN3; homolog of ABP-280; Larsen syndrome 1 (autosomal dominant); Non-muscle filamin; Thyroid autoantigen; Truncated ABP; Truncated actin-binding protein; unnamed protein product

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基因别名: ABP-278; ABP-280; ABPX; AOI; CSBS; CVD1; FGS2; FH1; FLN; FLN-A; FLN-B; FLN1; FLN1L; FLN3; FLNA; FLNB; FMD; LRS1; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; SCT; TABP; TAP; XLVD; XMVD

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UniProt ID: (Human) P21333, (Human) B2ZZ83

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Entrez Gene ID: (Human) 2316, (Human) 2317, (Rat) 293860, (Rat) 306204

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功能
G-protein coupled receptor binding RNA binding actin binding protein binding potassium channel regulator activity kinase binding small GTPase binding Fc-gamma receptor I complex binding protein homodimerization activity ion channel binding macromolecular complex binding cadherin binding SMAD binding actin filament binding GTPase binding DNA-binding transcription factor binding protein sequestering activity identical protein binding glycoprotein binding signal transducer activity protein kinase C binding transcription factor binding Rho GTPase binding Ral GTPase binding mu-type opioid receptor binding protein complex binding poly(A) RNA binding Rac GTPase binding molecular_function
参与通路
epithelial to mesenchymal transition adenylate cyclase-inhibiting dopamine receptor signaling pathway biological_process actin cytoskeleton organization actin cytoskeleton reorganization protein localization to cell surface negative regulation of protein catabolic process cilium assembly mRNA transcription from RNA polymerase II promoter positive regulation of transcription factor import into nucleus receptor clustering positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of sequence-specific DNA binding transcription factor activity early endosome to late endosome transport establishment of protein localization protein stabilization cytoplasmic sequestering of protein actin crosslink formation platelet aggregation mitotic spindle assembly keratinocyte development epithelial cell morphogenesis skeletal muscle tissue development cell differentiation blood coagulation, intrinsic pathway positive regulation of platelet activation negative regulation of transcription from RNA polymerase I promoter formation of radial glial scaffolds cerebral cortex development cell projection organization regulation of cell migration positive regulation of actin filament bundle assembly megakaryocyte development positive regulation of protein import into nucleus negative regulation of apoptotic process wound healing, spreading of cells release of sequestered calcium ion into cytosol cilium morphogenesis semaphorin-plexin signaling pathway protein localization to plasma membrane tubulin deacetylation establishment of Sertoli cell barrier positive regulation of substrate adhesion-dependent cell spreading positive regulation of potassium ion transmembrane transport protein localization to bicellular tight junction regulation of membrane repolarization during atrial cardiac muscle cell action potential regulation of membrane repolarization during cardiac muscle cell action potential positive regulation of neural precursor cell proliferation positive regulation of integrin-mediated signaling pathway positive regulation of neuron migration signal transduction muscle organ development cellular response to interferon-gamma
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