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Invitrogen
Phospho-FLNA/FLNB (Ser2152, Ser2107) Recombinant Rabbit Monoclonal Antibody (K01_2K92)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA567869
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_2K92
抗原
A synthetic phosphopeptide corresponding to residues surrounding Ser2152 of human Filamin A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
FLNA and FLNB encode filamin A and filamin B, large actin binding scaffold proteins that crosslink F actin into orthogonal networks and anchor signaling receptors and ion channels to the cytoskeleton. Each filamin forms a dimer through a C terminal domain and contains an N terminal actin binding module followed by multiple immunoglobulin like repeats that provide mechanical flexibility and sites for interaction with membrane proteins, small GTPases, kinases, and transcriptional regulators. FLNA is broadly expressed and crucial for cell migration, mechanosensing, platelet function, and neuronal development, whereas FLNB has prominent roles in skeletal patterning, chondrocyte differentiation, and tissue morphogenesis. Pathogenic variants in FLNA cause periventricular nodular heterotopia, cardiovascular anomalies, and platelet disorders, while FLNB mutations lead to skeletal dysplasias such as atelosteogenesis and boomerang dysplasia, highlighting nonredundant functions despite overlapping activities. Filamins serve as mechanotransducers that couple extracellular matrix forces to intracellular signaling and gene expression, and they are studied using actin dynamics assays, interaction proteomics, imaging of cytoskeletal architecture, and genetic perturbation in cellular and animal models.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABP-278; ABP-280; ABP-280 homolog; actin binding protein 280; Actin-binding protein 280; Actin-binding-like protein; Alpha-filamin; Beta-filamin; Endothelial actin-binding protein; Endothelial actin-binding protein 280); Fh1; Filamin A; Filamin B; Filamin homolog 1; filamin, alpha; filamin, beta; Filamin-1; Filamin-3; Filamin-A; Filamin-B; FLN-A; FLN-B; FLN1; FLN3; Non-muscle filamin; Thyroid autoantigen; Truncated ABP; Truncated actin-binding protein
基因别名: FLN; FLN1; FLN1L; FLN3; FLNA; FLNB; RGD1560614; TABP; TAP
Entrez Gene ID: (Rat) 293860, (Rat) 306204
glycoprotein binding
signal transducer activity
protein kinase C binding
protein binding
transcription factor binding
Rho GTPase binding
Ral GTPase binding
small GTPase binding
mu-type opioid receptor binding
protein complex binding
Fc-gamma receptor I complex binding
protein homodimerization activity
poly(A) RNA binding
SMAD binding
Rac GTPase binding
actin filament binding
molecular_function
actin binding
identical protein binding
epithelial to mesenchymal transition
adenylate cyclase-inhibiting dopamine receptor signaling pathway
biological_process
actin cytoskeleton organization
actin cytoskeleton reorganization
protein localization to cell surface
negative regulation of protein catabolic process
cilium assembly
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription factor import into nucleus
receptor clustering
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
early endosome to late endosome transport
establishment of protein localization
protein stabilization
cytoplasmic sequestering of protein
actin crosslink formation
platelet aggregation
mitotic spindle assembly
keratinocyte development
epithelial cell morphogenesis
skeletal muscle tissue development
cell differentiation
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