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Phospho-Filamin A (Ser2152) Polyclonal Antibody

查看其他24个Filamin A抗体

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Phospho-Filamin A (Ser2152) Polyclonal Antibody

产品信息

PA5-36643

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic phosphopeptide derived from human Filamin 1 around the phosphorylation site of Serine 2152
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2553631

产品详细信息

This antibody detects endogenous protein at a molecular weight of 280 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ABP-280; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); epididymis secretory sperm binding protein; filamin 1; filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin; unnamed protein product

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基因别名: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; FGS2; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD

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UniProt ID: (Human) P21333, (Mouse) Q8BTM8

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Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176

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功能
G-protein coupled receptor binding RNA binding actin binding protein binding potassium channel regulator activity kinase binding small GTPase binding Fc-gamma receptor I complex binding protein homodimerization activity ion channel binding macromolecular complex binding cadherin binding SMAD binding actin filament binding GTPase binding DNA-binding transcription factor binding protein sequestering activity glycoprotein binding signal transducer activity protein kinase C binding transcription factor binding Rho GTPase binding Ral GTPase binding mu-type opioid receptor binding protein complex binding poly(A) RNA binding Rac GTPase binding
参与通路
epithelial to mesenchymal transition adenylate cyclase-inhibiting dopamine receptor signaling pathway biological_process actin cytoskeleton organization actin cytoskeleton reorganization protein localization to cell surface negative regulation of protein catabolic process cilium assembly mRNA transcription from RNA polymerase II promoter positive regulation of transcription factor import into nucleus receptor clustering positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of sequence-specific DNA binding transcription factor activity early endosome to late endosome transport establishment of protein localization protein stabilization cytoplasmic sequestering of protein actin crosslink formation platelet aggregation mitotic spindle assembly negative regulation of transcription from RNA polymerase I promoter cell projection organization negative regulation of apoptotic process positive regulation of substrate adhesion-dependent cell spreading positive regulation of integrin-mediated signaling pathway blood coagulation, intrinsic pathway positive regulation of platelet activation formation of radial glial scaffolds cerebral cortex development regulation of cell migration positive regulation of actin filament bundle assembly megakaryocyte development positive regulation of protein import into nucleus wound healing, spreading of cells release of sequestered calcium ion into cytosol cilium morphogenesis semaphorin-plexin signaling pathway protein localization to plasma membrane tubulin deacetylation establishment of Sertoli cell barrier positive regulation of potassium ion transmembrane transport protein localization to bicellular tight junction regulation of membrane repolarization during atrial cardiac muscle cell action potential regulation of membrane repolarization during cardiac muscle cell action potential positive regulation of neural precursor cell proliferation positive regulation of neuron migration
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