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Invitrogen
Phospho-GRK1/GRK2 (Tyr13) Polyclonal Antibody
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Phospho-GRK1/GRK2 (Tyr13) Antibody (PA5-118740) in IHC (P)
Immunohistochemical analysis of Phospho-GRK1/GRK2 (Tyr13) in Human ovarian cancer using a Phospho-GRK1/GRK2 (Tyr13) polyclonal antibody (Product # PA5-118740). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the... View More
产品信息
PA5-118740
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GRK2(Accession P25098), corresponding to amino acid residues around phosphorylated Tyr13.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of GRK1/2 only when phosphorylated at Tyr13.
靶标信息
The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; Beta-ARK-1; G protein-coupled receptor kinase 1; G protein-coupled receptpr kinase 1; G-protein coupled receptor kinase 2; G-protein receptor kinase 1; G-protein-coupled receptor kinase 2; grk 2; rhodopsin kinase; Rhodopsin kinase GRK1; RK
基因别名: Adrbk-1; ADRBK1; BARK; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GPRK1; GRK-2; GRK1; GRK2; RHOK; RK
UniProt ID: (Mouse) Q99LL8, (Rat) P26817, (Human) Q15835, (Human) P25098, (Rat) Q63651
Entrez Gene ID: (Mouse) 110355, (Rat) 25238, (Human) 6011, (Human) 156, (Mouse) 24013, (Rat) 81760
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Edg-2 lysophosphatidic acid receptor binding
beta-adrenergic receptor kinase activity
rhodopsin kinase activity
alpha-2A adrenergic receptor binding
non-receptor serine/threonine protein kinase
regulation of the force of heart contraction
desensitization of G-protein coupled receptor protein signaling pathway
negative regulation of the force of heart contraction by chemical signal
protein phosphorylation
response to oxidative stress
signal transduction
G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway
heart development
response to organic cyclic compound
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
viral genome replication
receptor internalization
positive regulation of catecholamine secretion
termination of G-protein coupled receptor signaling pathway
follicle-stimulating hormone signaling pathway
negative regulation of G-protein coupled receptor protein signaling pathway
negative regulation of striated muscle contraction
viral entry into host cell
cardiac muscle contraction
aging
response to hydrogen peroxide
visual perception
regulation of G-protein coupled receptor protein signaling pathway
rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signaling pathway
protein autophosphorylation
G-protein coupled acetylcholine receptor signaling pathway
photoreceptor cell morphogenesis
response to light stimulus
positive regulation of phosphorylation
negative regulation of apoptotic process
response to stimulus
post-embryonic retina morphogenesis in camera-type eye
response to drug
