Invitrogen

Phospho-HDAC5/HDAC9 (Ser259, Ser220) Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
Phospho-HDAC5/HDAC9 (Ser259, Ser220) Polyclonal Antibody

产品信息

PA5-40215

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化 (IHC)

1:100-1:300
-

酶联免疫吸附实验 (ELISA)

1:10,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human HDAC5/9 around the phosphorylation site of S259/220.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2576598

产品详细信息

This antibody is predicted to react with mouse based on sequence homology.

靶标信息

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Antigen NY-CO-9; HD5; HD7; HD7b; HD9; hdac-9; histone deacetylase 4; histone deacetylase 4/5-related protein; Histone deacetylase 5; Histone deacetylase 7B; Histone deacetylase 9; histone deacetylase mHDA1; Histone deacetylase-related protein; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR

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基因别名: AI426555; AV022454; D030072B18Rik; HD5; HD7; HD7B; HD9; HDAC; Hdac4; HDAC5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; KIAA0600; KIAA0744; mHDA1; MITR; mKIAA0600; mKIAA0744; NY-CO-9

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UniProt ID: (Human) Q9UQL6, (Human) Q9UKV0, (Mouse) Q99N13

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Entrez Gene ID: (Human) 10014, (Human) 9734, (Mouse) 15184, (Mouse) 79221

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功能
RNA polymerase III transcription factor binding core promoter binding chromatin binding histone deacetylase activity protein kinase C binding protein binding transcription factor binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding transcription regulatory region DNA binding metal ion binding repressing transcription factor binding transcription corepressor activity core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding hydrolase activity protein kinase binding histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) histone modifying enzyme
参与通路
negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling chromatin silencing transcription, DNA-templated protein deacetylation inflammatory response regulation of myotube differentiation negative regulation of myotube differentiation response to activity chromatin modification histone deacetylation neuron differentiation B cell differentiation cellular response to insulin stimulus regulation of gene expression, epigenetic B cell activation response to cocaine response to drug regulation of protein binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity histone H3 deacetylation cellular response to lipopolysaccharide negative regulation of cell migration involved in sprouting angiogenesis regulation of histone H3-K9 acetylation response to amphetamine heart development peptidyl-lysine deacetylation regulation of skeletal muscle fiber development regulation of striated muscle cell differentiation histone H4 deacetylation positive regulation of cell migration involved in sprouting angiogenesis osteoblast development regulation of transcription, DNA-templated transcription from RNA polymerase II promoter nervous system development negative regulation of gene expression multicellular organismal response to stress negative regulation of osteoblast differentiation negative regulation of striated muscle tissue development renal tubule morphogenesis cellular response to fluid shear stress positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation
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