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Invitrogen
Phospho-HDAC5/HDAC9 (Ser259, Ser220) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-40215
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human HDAC5/9 around the phosphorylation site of S259/220.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with mouse based on sequence homology.
靶标信息
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HD5; HD7b; HD9; hdac-9; histone deacetylase 4; histone deacetylase 5; Histone deacetylase 7B; Histone deacetylase 9; histone deacetylase mHDA1; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR
基因别名: AI426555; AV022454; D030072B18Rik; HD7B; HD9; Hdac4; Hdac7b; Hdac9; HDRP; mHDA1; Mitr; mKIAA0600; mKIAA0744
UniProt ID: (Mouse) Q99N13
Entrez Gene ID: (Mouse) 15184, (Mouse) 79221
RNA polymerase III transcription factor binding
core promoter sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein kinase C binding
protein binding
transcription factor binding
hydrolase activity
protein kinase binding
histone deacetylase activity (H3-K14 specific)
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
protein deacetylase activity
histone deacetylase activity (H4-K16 specific)
histone deacetylase binding
transcription regulatory region DNA binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
repressing transcription factor binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
osteoblast development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein deacetylation
inflammatory response
nervous system development
heart development
negative regulation of gene expression
regulation of myotube differentiation
negative regulation of myotube differentiation
chromatin modification
histone deacetylation
B cell differentiation
multicellular organismal response to stress
regulation of gene expression, epigenetic
B cell activation
response to cocaine
response to drug
regulation of protein binding
negative regulation of osteoblast differentiation
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of skeletal muscle fiber development
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of striated muscle cell differentiation
renal tubule morphogenesis
cellular response to fluid shear stress
negative regulation of cell migration involved in sprouting angiogenesis
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation
cellular response to insulin stimulus
peptidyl-lysine deacetylation
histone H3 deacetylation
histone H4 deacetylation
positive regulation of cell migration involved in sprouting angiogenesis
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