Invitrogen

Phospho-HDAC5 (Ser498) Polyclonal Antibody

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Phospho-HDAC5 (Ser498) Polyclonal Antibody

Product Details

PA5-105041

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HDAC5(Accession Q9UQL6), corresponding to amino acid residues around phosphorylated Ser498.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816514

Product Specific Information

Antibody detects endogenous levels of HDAC5 only when phosphorylated at Serine 498.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Antigen NY-CO-9; DKFZp779K1053; FLJ90614; HD5; HD7; HD7b; HD9; HDAC; HDAC-5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4; Histone deacetylase 5; histone deacetylase mHDA1; KIAA0744

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Gene Aliases: AI426555; HD5; Hdac4; HDAC5; KIAA0600; mHDA1; mKIAA0600; NY-CO-9

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UniProt ID: (Human) Q9UQL6

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Entrez Gene ID: (Human) 10014, (Rat) 84580, (Mouse) 15184

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Function(s)
RNA polymerase III transcription factor binding core promoter binding chromatin binding histone deacetylase activity protein kinase C binding protein binding transcription factor binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding transcription regulatory region DNA binding metal ion binding repressing transcription factor binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcription corepressor activity protein kinase binding hydrolase activity histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) histone modifying enzyme
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling chromatin silencing transcription, DNA-templated protein deacetylation inflammatory response regulation of myotube differentiation negative regulation of myotube differentiation response to activity chromatin modification histone deacetylation neuron differentiation B cell differentiation cellular response to insulin stimulus regulation of gene expression, epigenetic B cell activation response to cocaine response to drug regulation of protein binding negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity histone H3 deacetylation cellular response to lipopolysaccharide negative regulation of cell migration involved in sprouting angiogenesis regulation of histone H3-K9 acetylation osteoblast development transcription from RNA polymerase II promoter heart development multicellular organismal response to stress negative regulation of osteoblast differentiation regulation of skeletal muscle fiber development regulation of striated muscle cell differentiation renal tubule morphogenesis cellular response to fluid shear stress positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation regulation of transcription, DNA-templated nervous system development negative regulation of gene expression negative regulation of striated muscle tissue development
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