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Invitrogen
Phospho-HSP90 (Ser255) Polyclonal Antibody
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Phospho-HSP90 (Ser255) Antibody (PA5-104775) in ICC/IF
Immunocytochemistry analysis of Phospho-HSP90 (Ser255) in Hela cells (20 min of 30 µM Forskolin treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-HSP90 (Ser255) polyclonal antibody (Product # PA5-104775) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated g... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104775
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HSP90AB1(Accession P08238), corresponding to amino acid residues around phosphorylated Ser255.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of Hsp90 beta only when phosphorylated at Ser255, which site historically referenced as Ser254.
靶标信息
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATHS83; AtHsp90-1; ATHSP90.1; F6N7.13; F6N7_13; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; HEAT SHOCK PROTEIN 81-1; HEAT SHOCK PROTEIN 83; heat shock protein 86; HEAT SHOCK PROTEIN 90-1; heat shock protein 90.1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; Heat shock protein family C member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP81-1; HSP81.1; HSP83; HSP84; HSP86; LAP-2; Lipopolysaccharide-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen
基因别名: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; hsp4; Hsp84; Hsp84-1; Hsp86; Hsp86-1; Hsp89; Hsp90; HSP90-BETA; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPC3; HSPCA; HSPCB
UniProt ID: (Mouse) P07901, (Rat) P82995, (Mouse) P11499, (Rat) P34058
Entrez Gene ID: (Mouse) 15519, (Rat) 299331, (Mouse) 15516, (Rat) 301252
nucleotide binding
UTP binding
CTP binding
mRNA binding
protein binding
ATP binding
GTP binding
ATPase activity
sulfonylurea receptor binding
protein kinase binding
protein phosphatase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
identical protein binding
protein homodimerization activity
ion channel binding
poly(A) RNA binding
GTPase binding
Rho GDP-dissociation inhibitor binding
unfolded protein binding
double-stranded RNA binding
kinase binding
Hsp90 family chaperone
neuron migration
protein folding
nitric oxide biosynthetic process
response to stress
response to unfolded protein
positive regulation of lamellipodium assembly
positive regulation of protein import into nucleus, translocation
protein refolding
protein import into mitochondrial outer membrane
positive regulation of nitric oxide biosynthetic process
positive regulation of cytotoxic T cell differentiation
positive regulation of cell size
regulation of catalytic activity
chaperone-mediated protein complex assembly
skeletal muscle contraction
response to heat
response to salt stress
cardiac muscle cell apoptotic process
response to estrogen
positive regulation of cardiac muscle contraction
placenta development
virion attachment to host cell
positive regulation of protein binding
negative regulation of neuron apoptotic process
cellular response to interleukin-4
positive regulation of protein serine/threonine kinase activity
fibril organization
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to organic cyclic compound
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