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Rockland
Phospho-Histone H2AvD (Ser137) Polyclonal Antibody
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Phospho-Histone H2AvD (Ser137) Antibody (600-401-914) in WB
Western blot using Rocklands affinity purified anti-histone H2AvD pS137 antibody shows detection of a band at ~15 kDa corresponding to phosphorylated H2AvD (lane 2 arrow-head). Lanes contain either mock-irradiated (lane 1) or 4000-RAD gamma irradiated (lane 2) Drosophila melanogaster (3rd instar) larvae brain WC lysate separated on by SDS-PAGE and transferred to nitrocellulose. After blocking the membrane... View More
产品信息
600-401-914
产品规格
种属反应
Fruit fly
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Histone H2AvD pS137 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-Terminal region near amino acids 125-141 of Drosophila melanogaster (fruit fly) H2AvD protein.
偶联物
形式
Liquid
浓度
1.1 mg/mL
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Affinity purified Anti-Histone H2AvD pS137 Antibody is directed against the phosphorylated form of Drosophila H2AvD protein at the pS137 residue. Reactivity occurs against Drosophila H2AvD pS137 protein and the antibody is specific for the phosphorylated form of the protein. Reactivity with non-phosphorylated Drosophila H2AvD is minimal by ELISA. A BLAST analysis was used to suggest little to no cross reactivity with H2AvD proteins from other sources based on a comparison using the immunizing sequence. Reactivity against homologues from other sources is not known.
靶标信息
Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. H2AvD is vital for viability, but the exact function of variant histones H2A is not known. H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 bp of DNA. HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only). The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur. In mouse, H2AX ''knock out'' mice have an increased incidence of cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CG5499-PA; CG5499-PB; H2A ; H2A.F/Z; H2A.Z; His2Av-PA; His2Av-PB; histone; histone ; histone 2A ; Histone H2A.v; histone H2Av; Histone-2A; Histone-2av; histone2A; histone2Av; histone2AvD; LD21568p; unnamed protein product
基因别名: *i H2av; 5499; CG5499; dHis2Av; Dmel\CG5499; Dmel_CG5499; gamma-H2AV; gamma-H2AvD; gamma-HIS2AV; gammaH2AV; gammaH2Ax; H2A; H2A.F/Z; H2A.V; H2A.X; H2A.Z; H2AV; H2AV_DROM; H2AvD; H2AX; H2AZ; HIS; His2; His2A; HIS2AV; HIS2AVD; HisH2Av; Hist; Hist2av; l(3)05146; l(3)810; l(3)97Dd; l(3)L1602
UniProt ID: (Fruit fly) P08985
Entrez Gene ID: (Fruit fly) 43229
