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Invitrogen
Phospho-IGF1R beta (Tyr1165, Tyr1166) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-IGF1R beta (Tyr1165, Tyr1166) Antibody (PA5-37602) in IHC (P)
Immunohistochemistry analysis of Phospho-IGF1R beta (Tyr1165, Tyr1166) in human colorectal cancer formalin fixed paraffin embedded tissue section. Samples were incubated with Phospho-IGF1R beta (Tyr1165, Tyr1166) polyclonal antibody (Product #PA5-37602).
Product Details
PA5-37602
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K) derived from Human IGF-1R.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for Western blot is 293 cells; suggested positive control for ICC/IF is MCF-7 cells.
Target Information
IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD221; IGF-I receptor; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
Gene Aliases: A330103N21Rik; CD221; D930020L01; hyft; IGF-1R; IGF1R; IGFIR; IGFIRC; IGFR; Igfr1; JTK13
UniProt ID: (Human) P08069, (Rat) P24062, (Mouse) Q60751
Entrez Gene ID: (Human) 3480, (Rat) 25718, (Mouse) 16001
protein tyrosine kinase activity
insulin-like growth factor-activated receptor activity
insulin receptor binding
protein binding
insulin-like growth factor binding
ATP binding
insulin-like growth factor I binding
identical protein binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
G-protein alpha-subunit binding
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
immune response
signal transduction
positive regulation of cell proliferation
insulin receptor signaling pathway
phosphatidylinositol 3-kinase signaling
positive regulation of cell migration
peptidyl-tyrosine autophosphorylation
negative regulation of apoptotic process
positive regulation of DNA replication
regulation of JNK cascade
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
protein tetramerization
inactivation of MAPKK activity
protein phosphorylation
axonogenesis
brain development
epidermis development
organ morphogenesis
negative regulation of muscle cell apoptotic process
establishment of cell polarity
male sex determination
mammary gland development
exocrine pancreas development
neuron projection development
positive regulation of cytokinesis
response to vitamin E
negative regulation of MAPK cascade
positive regulation of MAPK cascade
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of mitotic nuclear division
positive regulation of DNA metabolic process
protein heterooligomerization
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
prostate gland epithelium morphogenesis
positive regulation of steroid hormone biosynthetic process
transmembrane receptor protein tyrosine kinase signaling pathway
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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