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Invitrogen
Phospho-JunD (Ser255) Polyclonal Antibody
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Phospho-JunD (Ser255) Antibody (PA5-104821) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-JunD (Ser255) in human bladder cancer tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-JunD (Ser255) polyclonal antibody (Product # PA5-104821) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104821
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human JUND(Accession P17535), corresponding to amino acid residues around phosphorylated Ser255.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of JunD only when phosphorylated at Serine 255.
靶标信息
JunD is a transcription factor which is coded by JunD gene. JunD transcriptional activity is modulated by phosphorylation in response to cellular stress via the c-Jun N terminal kinase (JNK)/Stress-Activated Protein Kinase (SAPK) family of protein kinase. Jun proteins are capable of forming dimers with Fos, ATF and CREB family transcription factors to form the AP-1 complex that differentially regulates a variety of target genes involved in cellular growth, proliferation, differentiation and apoptosis. Also, JunD plays an important role in metabolism via modulation of IGF-1 signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AP1; JUN D; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; JunD-FL isoform; Oncogene Jun-D; Transcription factor AP-1 subunit JunD; transcription factor jun-D; Transcription factor JunD
基因别名: Jun-d; JUND; Jund1
UniProt ID: (Rat) P52909, (Mouse) P15066
Entrez Gene ID: (Rat) 24518, (Mouse) 16478
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
ligand-dependent nuclear receptor binding
enzyme binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
basic leucine zipper transcription factor
osteoblast development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
aging
circadian rhythm
response to light stimulus
response to mechanical stimulus
response to organic cyclic compound
response to lipopolysaccharide
response to peptide hormone
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to calcium ion
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to radiation
regulation of cell death
cellular response to hormone stimulus
response to cytokine
regulation of cell proliferation
response to drug
response to cAMP
regulation of cell cycle
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