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Invitrogen
Phospho-JunD (Ser255) Recombinant Rabbit Monoclonal Antibody (JJ08-21)
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Phospho-JunD (Ser255) Antibody (MA5-32444) in ICC/IF
Immunocytochemical analysis of Phospho-JunD (Ser255) in MCF-7 cells using a Phospho-JunD (Ser255) Monoclonal antibody (Product # MA5-32444) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
产品信息
MA5-32444
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JJ08-21
抗原
Synthetic phospho-peptide corresponding to residues surrounding Ser255 of Human JunD aa 251-270
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
JunD is a transcription factor which is coded by JunD gene. JunD transcriptional activity is modulated by phosphorylation in response to cellular stress via the c-Jun N terminal kinase (JNK)/Stress-Activated Protein Kinase (SAPK) family of protein kinase. Jun proteins are capable of forming dimers with Fos, ATF and CREB family transcription factors to form the AP-1 complex that differentially regulates a variety of target genes involved in cellular growth, proliferation, differentiation and apoptosis. Also, JunD plays an important role in metabolism via modulation of IGF-1 signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activator protein 1; AP1; JUN D; jun D proto-oncogene; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; JunD-FL isoform; Oncogene Jun-D; Transcription factor AP-1 subunit JunD; transcription factor jun-D; Transcription factor JunD
基因别名: AP-1; Jun-d; JUND; Jund1
UniProt ID: (Human) P17535, (Rat) P52909, (Mouse) P15066
Entrez Gene ID: (Human) 3727, (Rat) 24518, (Mouse) 16478
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
enzyme binding
transcription regulatory region DNA binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
osteoblast development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
aging
circadian rhythm
response to radiation
response to light stimulus
response to mechanical stimulus
regulation of cell death
response to lipopolysaccharide
cellular response to hormone stimulus
response to cytokine
regulation of cell proliferation
response to drug
response to peptide hormone
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
response to cAMP
regulation of cell cycle
cellular response to calcium ion
regulation of transcription, DNA-templated
response to organic cyclic compound
transcription, DNA-templated
