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Invitrogen
Phospho-KCNH2 (Ser1137) Polyclonal Antibody
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Phospho-KCNH2 (Ser1137) Antibody (PA5-105315) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-KCNH2 (Ser1137) in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-KCNH2 (Ser1137) polyclonal antibody (Product # PA5-105315) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105315
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KCNH2(Accession Q12809), corresponding to amino acid residues around phosphorylated Ser1137.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of KCNH2 only when phosphorylated at Ser1137.
靶标信息
Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Eag homolog; eag-related protein 1; ERG-1; Ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; HERG-1; M-erg1; Potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; RERG; Voltage-gated inwardly rectifying potassium channel KCNH2; Voltage-gated potassium channel subunit Kv11.1
基因别名: AI326795; ERG; ERG1; HERG; KCNH2; LQT; Lqt2; M-erg; Merg1; merg1a; merg1b
UniProt ID: (Mouse) O35219, (Rat) O08962
Entrez Gene ID: (Mouse) 16511, (Rat) 117018
phosphorelay sensor kinase activity
signal transducer activity
ion channel activity
inward rectifier potassium channel activity
voltage-gated ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
C3HC4-type RING finger domain binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
scaffold protein binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
protein binding
ion channel
phosphorelay signal transduction system
transport
ion transport
potassium ion transport
signal transduction
regulation of ion transmembrane transport
cellular response to drug
regulation of membrane potential
protein heterooligomerization
potassium ion homeostasis
transmembrane transport
cardiac muscle contraction
regulation of membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
potassium ion export
potassium ion transmembrane transport
ventricular cardiac muscle cell action potential
membrane depolarization during action potential
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
potassium ion export across plasma membrane
regulation of potassium ion transmembrane transport
negative regulation of potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
negative regulation of potassium ion export
brain development
spinal cord development
signal transduction by protein phosphorylation
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