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Phospho-LATS1/LATS2 (Thr1079, Thr1041) Recombinant Rabbit Monoclonal Antibody (3R10U0)
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Phospho-LATS1/LATS2 (Thr1079, Thr1041) Antibody (MA569914) in ICC/IF
Immunocytochemical analysis of Phospho-LATS1/LATS2 (Thr1079, Thr1041) in NIH/3T3 cells. Samples were incubated with Phospho-LATS1/LATS2 (Thr1079, Thr1041) recombinant monoclonal antibody (Product # MA569914) using a dilution of 1:200 (40x lens). Followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) using a dilution of 1:500 (Red). DAPI was used for nuclear staining (Blue).
产品信息
MA569914
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3R10U0
抗原
Synthetic peptide.
偶联物
形式
Liquid
浓度
1.3 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3., with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: h-warts; Kinase phosphorylated during mitosis protein; large tumor suppressor 2; Large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; lats1; lats2; putative serine threonine kinase; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; Serine/threonine-protein kinase LATS2; similar to Drosophila warts tumor suppressor; unnamed protein product; WARTS protein kinase; Warts-like kinase
基因别名: 4932411G09Rik; AV277261; AW208599; AW228608; KPM; LATS1; LATS2; RGD1564085; WARTS; wts
UniProt ID: (Human) O95835, (Human) Q9NRM7, (Mouse) Q8BYR2, (Mouse) Q7TSJ6
Entrez Gene ID: (Human) 9113, (Human) 26524, (Rat) 308265, (Mouse) 16798, (Mouse) 50523, (Rat) 305922
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
estrogen receptor binding
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
sister chromatid segregation
inner cell mass cell fate commitment
inner cell mass cellular morphogenesis
protein phosphorylation
protein localization
hormone-mediated signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
keratinocyte differentiation
regulation of actin filament polymerization
regulation of intracellular estrogen receptor signaling pathway
hippo signaling
positive regulation of hippo signaling
positive regulation of apoptotic process
regulation of protein complex assembly
NLRP3 inflammasome complex assembly
mitotic cell cycle phase transition
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of organ growth
cell division
mammary gland epithelial cell differentiation
negative regulation of canonical Wnt signaling pathway
regulation of postsynaptic density assembly
negative regulation of protein localization to nucleus
positive regulation of NLRP3 inflammasome complex assembly
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
intracellular signal transduction
canonical Wnt signaling pathway
mitotic nuclear division
positive regulation of peptidyl-serine phosphorylation
cellular protein localization
cytoplasmic sequestering of protein
cell cycle
phosphorylation
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