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Invitrogen
Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody
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Phospho-LIMK1/LIMK2 (Thr508, Thr505) Antibody (PA5-104924) in IHC (P)
Immunohistochemistry analysis of Phospho-LIMK1/LIMK2 (Thr508, Thr505) in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-LIMK1/LIMK2 (Thr508, Thr505) polyclonal antibody (Product # PA5-104924) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody... View More
产品信息
PA5-104924
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human LIMK1(Accession P53667), corresponding to amino acid residues around phosphorylated Thr508.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of LIMK1/2 only when phosphorylated at Threonine 508/505.
靶标信息
Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: KIZ-1; LIM domain kinase 1; LIM domain kinase 2; lim kinase 1; LIM kinase 2; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM motif-containing protein kinase 2; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase 1; LIMK 2; LIMK-1; LIMK-2
基因别名: KIZ-1; LIMK; LIMK-1; Limk-2; LIMK1; LIMK2; Limk2b; Link2
UniProt ID: (Human) P53667, (Human) P53671, (Mouse) P53668, (Mouse) O54785, (Rat) P53670
Entrez Gene ID: (Human) 3984, (Human) 3985, (Mouse) 16885, (Rat) 65172, (Mouse) 16886, (Rat) 29524
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
zinc ion binding
heat shock protein binding
protein heterodimerization activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
protein phosphorylation
spermatogenesis
phosphorylation
spermatid development
signal transduction
Rho protein signal transduction
nervous system development
actin cytoskeleton organization
positive regulation of actin filament bundle assembly
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of axon extension
negative regulation of ubiquitin-protein transferase activity
positive regulation of stress fiber assembly
