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Phospho-LRP6 (Ser1490) Antibody (PA5-78045) in WB
Western Blot using Phospho-LRP6 (Ser1490) Polyclonal Antibody (Product # PA5-78045). Untreated (–) and treated (+) HeLa whole cell extracts (30 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with LRP6 phospho S1490 antibody Phospho-LRP6 (Ser1490) Polyclonal Antibody (Product # PA5-78045) diluted at 1:1,000. (CIP: Calf-intestinal alkaline phosphatase).
产品信息
PA5-78045
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human LRP6 (phospho Ser1490). The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736389
产品详细信息
Positive Control: 293T, A431, HeLa, HepG2
Predicted Reactivity: Mouse (100%), Xenopus laevis (100%), Rhesus Monkey (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6
基因别名: ADCAD2; LRP6; STHAG7
UniProt ID: (Human) O75581
Entrez Gene ID: (Human) 4040
low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
apolipoprotein binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway
apolipoprotein
neural tube closure
negative regulation of protein phosphorylation
pericardium morphogenesis
negative regulation of protein kinase activity
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
embryonic pattern specification
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
single organismal cell-cell adhesion
cerebellum morphogenesis
thalamus development
cerebral cortex development
midbrain-hindbrain boundary development
negative regulation of smooth muscle cell apoptotic process
external genitalia morphogenesis
odontogenesis of dentin-containing tooth
response to peptide hormone
Wnt signaling pathway involved in dorsal/ventral axis specification
canonical Wnt signaling pathway involved in neural crest cell differentiation
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
convergent extension
embryonic retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
face morphogenesis
trachea cartilage morphogenesis
cellular response to cholesterol
dopaminergic neuron differentiation
negative regulation of protein serine/threonine kinase activity
protein localization to plasma membrane
primitive streak formation
negative regulation of canonical Wnt signaling pathway
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Wnt signaling pathway involved in somitogenesis
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
toxin transport
beta-catenin destruction complex disassembly
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
