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Positive Control: COLO205 cell lysate, TT cell lysate, Ramos serum starved for 16 hours cell lysate, Ramos serum starved for 16 hours add 12 µg/mL human IgM (diluted in serum free medium) for 2 minutes cell lysate, NIH/3T3 cell lysate, NIH/3T3 treated with 50mM sodium orthovanadate for 5 minutes cell lysate, PC-12 cell lysate, PC-12 treated with 1mM sodium orthovanadate for 30 minutes cell lysate, Ramos cells serum starved for 16 hours add 12 µg/mL human IgM (diluted in serum free medium) for 2 minutes.
Tissue Specificity: Tissue enhanced (bone marrow, lymphoid tissue).
Subcellular Location: Cell membrane, Cytoplasm, cytosol.
Sequence Similarities: 100% Mouse/Rat.
Predicted band size: 58 kDa
The LYN, LCK, HCK, and BLK genes encode various members of the Src family of non-receptor tyrosine kinases, each playing crucial roles in cellular signaling pathways that regulate immune function, cell proliferation, and differentiation. LYN is involved in B-cell receptor signaling, influencing cell proliferation, differentiation, apoptosis, migration, metabolism, and roles in inflammation and cancer, particularly within the immune system and oncogenic pathways. LCK is primarily expressed in T-cells and is crucial for T-cell development, function, and signaling, impacting cytokine production and immune responses. HCK, primarily found in hematopoietic cells, influences myeloid cell function and is implicated in oncogenic signaling pathways, potentially contributing to cancer progression via altered immune responses. BLK participates mainly in B-cell receptor signaling, impacting B-cell development and activation, with implications for immune cell signaling and potential roles in autoimmune diseases. Each of these kinases is a potential therapeutic target, given their roles in various pathophysiological conditions and their impact on immune cell signaling and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: B cell/myeloid kinase; B lymphocyte kinase; B lymphoid tyrosine kinase; B-cell/myeloid kinase; BLK nonreceptor tyrosine kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; hemopoietic cell tyrosine kinase; Lck/Yes-related novel protein tyrosine kinase; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; lymphocyte-specific protein tyrosine kinase; lyn protein non-receptor kinase; p53Lyn; p55-Blk; p56(LSTRA) protein-tyrosine kinase; p56-HCK; p56-HCK/p59-HCK; p56-LCK; p56Hck; p56Lyn; p59-HCK/p60-HCK; p59Hck; p61Hck; Protein YT16; Proto-oncogene Lck; Proto-oncogene tyrosine-protein kinase LCK; T cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck; Tyrosine-protein kinase Blk; Tyrosine-protein kinase HCK; Tyrosine-protein kinase Lck; Tyrosine-protein kinase Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
基因别名:
AA407514; AI849071; BLK; Bmk; HCK; Hck-2; Hck-3; Hctk; IMD22; JTK8; JTK9; LCK; Lck1; Lcktkr; LSK; Lsk-t; Lskt; LYN; MODY11; p53Lyn; p56
UniProt ID: (Human) P51451, (Mouse) P16277, (Human) P08631, (Rat) P50545, (Mouse) P08103, (Human) P06239, (Human) P07948, (Rat) Q01621, (Mouse) P06240, (Mouse) P25911, (Rat) Q07014
Entrez Gene ID: (Human) 640, (Mouse) 12143, (Rat) 364403, (Human) 3055, (Rat) 25734, (Mouse) 15162, (Human) 3932, (Human) 4067, (Rat) 313050, (Mouse) 16818, (Mouse) 17096, (Rat) 81515