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7TM Antibodies
Phospho-Lysophosphatidic Acid Receptor 1 (Ser344, Ser346, Ser347) Polyclonal Antibody
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Phospho-Lysophosphatidic Acid Receptor 1 (Ser344, Ser346, Ser347) Antibody (7TM0272B) in WB
Agonist-induced Serine344/Serine346/Serine347 phosphorylation of the Lysophosphatidic Acid Receptor 1. Upper panel, HEK293 cells stably expressing the LPA1-Receptor (LPA1) were either not exposed or exposed to 1 µM of LPA1-Receptor agonists 1-oleoyl-LPA for 30 minutes. Cells were lysed and immunoblotted with the anti-pS344/pS346/pS347-LPA1 antibody (7TM00272B) at a dilution of 1:1,000. Lower panel, blot was... View More
产品信息
7TM0272B
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human LPA1 around the phosphorylation site of Ser344/Ser346/Ser347.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EDG2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2; unnamed protein product; ventricular zone gene 1
基因别名: edg-2; EDG2; Gpcr26; LPA1; LPAR1; Mrec1.3; rec.1.3; vzg-1; VZG1
UniProt ID: (Human) Q92633
Entrez Gene ID: (Human) 1902
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
negative regulation of neuron projection development
oligodendrocyte development
cerebellum development
optic nerve development
neurogenesis
corpus callosum development
bleb assembly
positive regulation of Rho protein signal transduction
myelination
Golgi to plasma membrane protein transport
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cilium assembly
positive regulation of stress fiber assembly
cell chemotaxis
regulation of vesicle-mediated transport
positive regulation of dendritic spine development
protein localization to cilium
cellular response to oxygen levels
positive regulation of smooth muscle cell chemotaxis
regulation of synaptic vesicle cycle
regulation of postsynaptic neurotransmitter receptor internalization
negative regulation of cAMP/PKA signal transduction
negative regulation of cilium assembly
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
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