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7TM Antibodies
Phospho-M2 Muscarinic Acetylcholine Receptor (Thr310, Ser311) Polyclonal Antibody
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Phospho-M2 Muscarinic Acetylcholine Receptor (Thr310, Ser311) Antibody (7TM0014E) in WB
Agonist-induced Threonine310/Serine311 phosphorylation of the M2 Muscarinic Acetylcholine Receptor. Upper panel, HEK293 cells stably expressing the M2 Muscarinic Acetylcholine Receptor (M2) were either not exposed or exposed to 100 nM Carbachol for 30 minutes. Cells were lysed and immunoblotted with the anti-pT310/pS311-5-HT4 antibody (7TM0014E) at a dilution of 1:1,000. Lower panel, blot was stripped and r... View More
产品信息
7TM0014E
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human M2 around the phosphorylation site of Thr310/Ser311.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; cholinergic receptor; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a; FLJ43243; M2-mAChR; m2AChR; MGC120006; MGC120007; Muscarinic acetylcholine receptor M2; muscarinic M2 receptor
基因别名: CHRM2; HM2
UniProt ID: (Human) P08172
Entrez Gene ID: (Human) 1129
regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
nervous system development
regulation of heart contraction
response to virus
