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7TM Antibodies
Phospho-M4 Muscarinic Acetylcholine Receptor (Thr311, Ser314) Polyclonal Antibody
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Phospho-M4 Muscarinic Acetylcholine Receptor (Thr311, Ser314) Antibody (7TM0016B) in WB
Agonist-induced Threonine311/Serine314 phosphorylation of the M4 Muscarinic Acetylcholine Receptor. Upper panel, HEK293 cells stably expressing the M4 Muscarinic Acetylcholine Receptor (M4) were either not exposed or exposed to 100 µM Carbachol for 30 minutes. Cells were lysed and immunoblotted with the anti-pT311/pS314-M4 antibody (7TM0016B) at a dilution of 1:1,000. Lower panel, blot was stripped and repr... View More
产品信息
7TM0016B
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human M4 around the phosphorylation site of Thr311/Ser314.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Muscarinic acetylcholine receptor M4 is an Acetylcholine Receptor. Unlike muscarinic receptor M2, the M4 receptor is not involved in smooth muscle contraction. The clinical relevance of this receptor is unknown. However, mouse studies have linked it to adenylyl cyclase inhibition. Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particularly the striatum and hippocampus. ESTs have been isolated from human breast and eye libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 4; cholinergic receptor; cholinergic receptor, muscarinic 4; Muscarinic acetylcholine receptor M4
基因别名: CHRM4; HM4; M4R
UniProt ID: (Human) P08173
Entrez Gene ID: (Human) 1132
signal transduction
cell surface receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
cell proliferation
regulation of locomotion
positive regulation of GTPase activity
