Invitrogen

Phospho-MYLK (Ser19) Polyclonal Antibody

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Phospho-MYLK (Ser19) Polyclonal Antibody

产品信息

44-260G

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
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产品规格

种属反应

Chicken, Human

已发表种属

Bovine, Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of MLC that contains serine 19 (serine 20 including the initiating methionine).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533618

靶标信息

MYLK (MLCK) is a serine/threonine kinase that phosphorylates myosin regulatory light chains to assist in the production of contractile activity (myosin-actin interaction). MLCK is responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: A clone isolated from a chicken gizzard cDNA library which has high homology with the 3'-end sequence of the chicken gizzard myosin light chain kinase (MLCK) cDNA; The 5'-leader seqeuence derives from the intronic sequence of the MLCK gene.; kinase related protein; Kinase-related protein; KRP; MLCK; Myosin light chain kinase, smooth muscle; myosin, light polypeptide kinase; smooth muscle myosin light chain kinase; smooth muscle myosin light chain kinase (61-kDa active fragment); smooth muscle myosin light chain kinase precursor (EC 2.7.2.37); Telokin; unnamed protein product

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基因别名: AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK; MYLK1; smMLCK

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UniProt ID: (Human) Q15746

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Entrez Gene ID: (Human) 4638, (Chicken) 396445

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