NeoBiotechnologies

Phospho-Myelin Basic Protein (Marker of Oligodendrocytes and Myelin) (Thr98) Monoclonal Antibody (MBP/4276)

Phospho-Myelin Basic Protein (Marker of Oligodendrocytes and Myelin) (Thr98) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-Myelin Basic Protein (Marker of Oligodendrocytes and Myelin) (Thr98) Antibody (4155-MSM6-P0) in IHC (P)

Formalin-fixed, paraffin-embedded human brain stained with Myelin Basic Protein Mouse Monoclonal Antibody (MBP/4276).

Phospho-Myelin Basic Protein (Marker of Oligodendrocytes and Myelin) (Thr98) Antibody in Western Blot (WB)

Phospho-Myelin Basic Protein (Marker of Oligodendrocytes and Myelin) (Thr98) Antibody in SDS-PAGE (SDS-PAGE)

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产品信息

4155-MSM6-P0

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL

免疫细胞化学 (ICC/IF)

1-2 µg/mL

酶联免疫吸附实验 (ELISA)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

MBP/4276

抗原

Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C, do not freeze

运输条件

Wet ice

靶标信息

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

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