Invitrogen

Phospho-NMDAR1 (Ser897) Polyclonal Antibody

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说明书
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说明书
实验方案
问题与答案
技术支持
Phospho-NMDAR1 (Ser897) Polyclonal Antibody

产品信息

PA5-104970

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human GRIN1(Accession Q05586), corresponding to amino acid residues around phosphorylated Ser897.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2816443

产品详细信息

Antibody detects endogenous levels of NMDAR1 only when phosphorylated at Serine 897.

靶标信息

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: GluN1; Glun1r; glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1

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基因别名: GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; M100174; MRD8; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Human) Q05586, (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810

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功能
NMDA glutamate receptor activity Ras guanyl-nucleotide exchange factor activity extracellular-glutamate-gated ion channel activity calcium channel activity calcium ion binding protein binding calmodulin binding glycine binding glutamate binding enzyme binding voltage-gated cation channel activity glutamate receptor binding neurotransmitter binding protein heterodimerization activity ionotropic glutamate receptor activity receptor binding cation channel activity protein dimerization activity receptor activity ion channel activity transmembrane signal receptor
参与通路
MAPK cascade conditioned taste aversion suckling behavior response to amphetamine cation transport cellular calcium ion homeostasis chemical synaptic transmission respiratory gaseous exchange long-term memory adult locomotory behavior olfactory learning visual learning propylene metabolic process sensory perception of pain pons maturation cerebral cortex development regulation of ion transmembrane transport social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic regulation of membrane potential positive regulation of apoptotic process response to morphine negative regulation of neuron apoptotic process positive regulation of GTPase activity regulation of respiratory gaseous exchange response to ethanol positive regulation of transcription from RNA polymerase II promoter ephrin receptor signaling pathway regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis protein tetramerization response to calcium ion regulation of synapse assembly calcium ion homeostasis excitatory postsynaptic potential prepulse inhibition male mating behavior response to fungicide calcium ion transmembrane transport cellular response to manganese ion positive regulation of excitatory postsynaptic potential startle response calcium ion transport learning or memory learning memory associative learning regulation of cell communication positive regulation of cell death response to organic cyclic compound response to amine ion transmembrane transport regulation of neuron apoptotic process regulation of synaptic plasticity regulation of neuronal synaptic plasticity neuromuscular process transport ion transport cation transmembrane transport
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