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Antibody detects endogenous levels of NOTCH3 only when phosphorylated at Ser84.
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Neurogenic locus notch homolog protein 3; Notch 3; Notch gene homolog 3; Notch homolog 3
基因别名: AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; NOTCH3
UniProt ID: (Human) Q9UM47, (Rat) Q9R172, (Mouse) Q61982
Entrez Gene ID: (Human) 4854, (Rat) 56761, (Mouse) 18131
分子生物学功能: cell adhesion molecule