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Phospho-PDE4A (Thr34) Polyclonal Antibody
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图: 1 / 1
Phospho-PDE4A (Thr34) Antibody (PPD4-140AP) in WB
WB using PPD4-140AP to detect increased phosphorylation of PDE4A6 in short-term FSK stimulation compared to the unchanged amount of PDE4A6 at 87 kDa. Image courtesy of Bing Zhu, et al. Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. Biochemical pharmacology 68.3 (2004): 479-491.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PPD4-140AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to PKA phosphorylation site on PDE4A long form enzymes. The peptide was synthesized with phosphorylated serine residue.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cAMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase PDE4A; cyclic AMP (cAMP)-specific phosphodiesterase; cyclic AMP specific phosphodiesterase family 4 sub-family A isoform 11; cyclic AMP specific phosphodiesterase PDE4A5A; cyclic nucleotide phosphodiesterase; dunce; long form PDE4A; PDE4A10 cAMP phosphodiesterase; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4; similar to Pde4a1; type-IVA cyclic AMP specific phosphodiesterase HPDE4A; unnamed protein product
基因别名: D9Ertd60e; DPDE2; PDE4; PDE46; PHOSA
UniProt ID: (Human) P27815, (Mouse) O89084, (Rat) P54748
Entrez Gene ID: (Human) 5141, (Mouse) 18577, (Rat) 25638
cAMP catabolic process
signal transduction
sensory perception of smell
modulation of synaptic transmission
cellular response to xenobiotic stimulus
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of cAMP/PKA signal transduction
negative regulation of cAMP/PKA signal transduction
G-protein coupled receptor signaling pathway
response to xenobiotic stimulus
Disclaimer
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