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Invitrogen
Phospho-PDE4D (Ser715) Polyclonal Antibody
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Phospho-PDE4D (Ser715) Antibody (PA5-106022) in ICC/IF
Immunofluorescent analysis of Phospho-PDE4D (Ser578) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-PDE4D (Ser578) polyclonal antibody (Product # PA5-106022) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 59... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106022
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PDE4D(Accession Q08499), corresponding to amino acid residues around phosphorylated Ser715.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of PDE4D only when phosphorylated at Ser715.
靶标信息
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3',5'-cyclic AMP phosphodiesterase; alternatively spliced; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE4D1; PDE4D10; PDE4D11; PDE4D2_v1; PDE4D2_v2; PDE4D2_v3; PDE4D3; PDE4D6; PDE4D7; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); splice variant PDE4D4; testicular tissue protein Li 136; unnamed protein product
基因别名: 9630011N22Rik; ACRDYS2; DPDE3; HSPDE4D; PDE3/IVd; PDE43; PDE4DN2; STRK1
UniProt ID: (Human) Q08499, (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Human) 5144, (Rat) 24627, (Mouse) 238871
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calcium channel regulator activity
protein binding
phosphoric diester hydrolase activity
enzyme binding
receptor regulator activity
cAMP binding
beta-2 adrenergic receptor binding
ion channel binding
3',5'-cyclic-GMP phosphodiesterase activity
ATPase binding
scaffold protein binding
heterocyclic compound binding
cyclic-nucleotide phosphodiesterase activity
ovulation from ovarian follicle
positive regulation of protein phosphorylation
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
signal transduction
memory
positive regulation of heart rate
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
positive regulation of cell-cell adhesion
lung development
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
multicellular organism growth
negative regulation of heart contraction
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
leukocyte migration
establishment of endothelial barrier
protein-containing complex assembly
cellular response to lipopolysaccharide
cellular response to cAMP
cellular response to follicle-stimulating hormone stimulus
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP/PKA signal transduction
regulation of cAMP/PKA signal transduction
negative regulation of cAMP/PKA signal transduction
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of relaxation of cardiac muscle
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of G-protein coupled receptor protein signaling pathway
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