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Invitrogen
Phospho-PKC alpha/beta-2 (Thr638, Thr641) Recombinant Rabbit Monoclonal Antibody (8D8L5)
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Phospho-PKC alpha/beta-2 (Thr638, Thr641) Antibody (MA5-55521) in WB
Western blot analysis of lysates from 293T cells, using Phospho-PKC alpha/beta-2 (Thr638, Thr641) Recombinant Monoclonal Antibody (Product # MA5-55521) at 1:6,000 dilution. 293T cells were treated by CIP(20μL/400μL) at 37&(8)451; for 1 hour. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) secondary antibody at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry ... View More
产品信息
MA5-55521
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8D8L5
抗原
A synthetic phosphorylated peptide around T638 of human PRKCA.
偶联物
形式
Liquid
浓度
0.69 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
RRID
靶标信息
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PKC-B; PRKC Pan; Protein kinase C beta type; protein kinase C, beta 1 polypeptide
基因别名: PKC-beta; PKCB; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P05771
Entrez Gene ID: (Human) 5579
chromatin binding
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein kinase C binding
calcium channel regulator activity
protein binding
ATP binding
zinc ion binding
ligand-dependent nuclear receptor transcription coactivator activity
histone kinase activity (H3-T6 specific)
histone binding
androgen receptor binding
non-receptor serine/threonine protein kinase
response to hypoxia
adaptive immune response
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
calcium ion transport
cellular calcium ion homeostasis
apoptotic process
mitotic nuclear envelope disassembly
signal transduction
negative regulation of glucose transport
peptidyl-serine phosphorylation
platelet activation
positive regulation of vascular endothelial growth factor receptor signaling pathway
histone H3-T6 phosphorylation
intracellular signal transduction
B cell activation
lipoprotein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
negative regulation of insulin receptor signaling pathway
B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
cellular response to carbohydrate stimulus
