Invitrogen

Phospho-PKC alpha/delta (Thr410) Recombinant Rabbit Monoclonal Antibody (5W5G1)

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说明书
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Phospho-PKC alpha/delta (Thr410) Recombinant Rabbit Monoclonal Antibody (5W5G1)

产品信息

MA5-55196

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

5W5G1

抗原

A synthetic phosphorylated peptide around T410 of human PRKCZ.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.41 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.05% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

RRID

AB_3667441

产品详细信息

Immunogen Sequence: TTSTFC

靶标信息

PKC alpha/delta refers to the protein kinase C isoforms alpha and delta, which are gene targets involved in various cellular processes and signaling pathways. Protein kinase C (PKC) is a family of enzymes that play a crucial role in regulating cell growth, differentiation, and intracellular signaling. PKC alpha and delta isoforms are widely expressed in different tissues and have distinct functions. PKC alpha is involved in cell proliferation, apoptosis, and cell cycle regulation, while PKC delta is implicated in cellular responses to stress, DNA damage, and apoptosis. These isoforms are activated by various stimuli, including second messengers and receptor-mediated signaling, leading to the phosphorylation of downstream targets and modulation of cellular processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: nPKC-delta; PKCA; PRKACA; Protein kinase C; Protein kinase C delta type; protein kinase C delta VIII; protein kinase C, delta; Tyrosine-protein kinase PRKCD

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基因别名: ALPS3; CVID9; MAY1; nPKC-delta; PKCD; PRKCD

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UniProt ID: (Human) Q05655

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Entrez Gene ID: (Human) 5580

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功能
protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding enzyme activator activity enzyme binding kinase binding protein kinase binding insulin receptor substrate binding metal ion binding non-receptor serine/threonine protein kinase
参与通路
stimulatory C-type lectin receptor signaling pathway protein phosphorylation apoptotic process cellular component disassembly involved in execution phase of apoptosis cell cycle signal transduction activation of phospholipase C activity intrinsic apoptotic signaling pathway in response to oxidative stress regulation of receptor activity immunoglobulin mediated immune response histone phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation termination of signal transduction platelet activation negative regulation of actin filament polymerization positive regulation of endodeoxyribonuclease activity negative regulation of protein binding activation of protein kinase activity interleukin-10 production interleukin-12 production positive regulation of superoxide anion generation regulation of actin cytoskeleton organization negative regulation of glial cell apoptotic process positive regulation of protein dephosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis B cell proliferation neutrophil activation positive regulation of protein import into nucleus defense response to bacterium negative regulation of MAP kinase activity regulation of mRNA stability negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response negative regulation of peptidyl-tyrosine phosphorylation protein stabilization negative regulation of filopodium assembly cell chemotaxis interferon-gamma-mediated signaling pathway cellular response to hydrogen peroxide cellular response to hydroperoxide negative regulation of platelet aggregation cellular senescence positive regulation of phospholipid scramblase activity cellular response to angiotensin positive regulation of ceramide biosynthetic process positive regulation of glucosylceramide catabolic process positive regulation of sphingomyelin catabolic process positive regulation of response to DNA damage stimulus positive regulation of apoptotic signaling pathway
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