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产品信息
PA1-28462
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide derived from the region of human PKC delta that contains serine 645.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_1959685
产品详细信息
Recommended positive controls: U937 cells.
It detects a band approximately 77kDa.
靶标信息
The PKC family of serine/threonine kinases, including PRKCD (PKC delta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
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生物信息学
蛋白别名: 1-May; kinase nPKC-delta; KPCD; nPKC-delta; Protein kinase C delta type; protein kinase C delta VIII; protein kinase C, delta; Tyrosine-protein kinase PRKCD
基因别名: ALPS3; CVID9; MAY1; nPKC-delta; PKCD; PRKCD
UniProt ID: (Human) Q05655
Entrez Gene ID: (Human) 5580
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-independent protein kinase C activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
enzyme activator activity
enzyme binding
kinase binding
protein kinase binding
insulin receptor substrate binding
metal ion binding
non-receptor serine/threonine protein kinase
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
cell cycle
signal transduction
activation of phospholipase C activity
intrinsic apoptotic signaling pathway in response to oxidative stress
regulation of receptor activity
immunoglobulin mediated immune response
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
termination of signal transduction
platelet activation
negative regulation of actin filament polymerization
positive regulation of endodeoxyribonuclease activity
negative regulation of protein binding
activation of protein kinase activity
interleukin-10 production
interleukin-12 production
positive regulation of superoxide anion generation
regulation of actin cytoskeleton organization
negative regulation of glial cell apoptotic process
positive regulation of protein dephosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
neutrophil activation
positive regulation of protein import into nucleus
defense response to bacterium
negative regulation of MAP kinase activity
regulation of mRNA stability
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of peptidyl-tyrosine phosphorylation
protein stabilization
negative regulation of filopodium assembly
cell chemotaxis
interferon-gamma-mediated signaling pathway
cellular response to hydrogen peroxide
cellular response to hydroperoxide
negative regulation of platelet aggregation
cellular senescence
positive regulation of phospholipid scramblase activity
cellular response to angiotensin
positive regulation of ceramide biosynthetic process
positive regulation of glucosylceramide catabolic process
positive regulation of sphingomyelin catabolic process
positive regulation of response to DNA damage stimulus
positive regulation of apoptotic signaling pathway
