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Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms ( alpha, betaI, betaII and gamma) and novel (n) PKC isoforms ( delta, epsilon, zeta, eta and theta). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and epsilon are independent of Ca2+.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 14 - 3 - 3 - zeta isoform; aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; nPKC-delta; nPKC-epsilon; nPKC-eta; nPKC-iota; nPKC-theta; nPKC-zeta; PKC zeta; PKC-A; PKC-alpha; PKC-B; PKC-beta; PKC-gamma; PKC-L; PRKC-lambda/iota; protein kinase C alpha type; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; Protein kinase C delta type; protein kinase C delta VIII; Protein kinase C epsilon type; Protein kinase C eta type; Protein kinase C gamma type; Protein kinase C iota type; Protein kinase C theta type; protein kinase C type I (gamma type); Protein kinase C zeta type; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase C, delta; protein kinase C, epsilon; protein kinase C, eta; protein kinase C, gamma; protein kinase C, iota; protein kinase C, lambda; protein kinase C, theta; protein kinase C, zeta; protein kinase C-eta; Tyrosine-protein kinase PRKCD
基因别名: 14-3-3-zetaisoform; ALPS3; CVID9; DXS1179E; MAY1; nPKC-delta; nPKC-epsilon; nPKC-eta; nPKC-iota; nPKC-theta; PKC; PKC-beta; PKC-gamma; PKC-L; PKC-ZETA; PKC2; Pkca; PKCB; PKCC; PKCD; PKCE; PKCG; Pkch; PKCI; PKCL; Pkcq; Pkcz; Prkc; PRKCB; PRKCB1; PRKCB2; Prkcc; PRKCD; PRKCE; PRKCG; PRKCH; PRKCI; PRKCL; PRKCQ; PRKCT; PRKCZ; r14-3-3; RATPKCI; SCA14