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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PTEN Antibodies

          Invitrogen

          Phospho-PTEN (Thr383) Polyclonal Antibody

          查看其他23个PTEN抗体

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          Cite Phospho-PTEN (Thr383) Polyclonal Antibody

          • 抗体检测数据 (4)
          Phospho-PTEN (Thr383) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Phospho-PTEN (Thr383) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 4

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          Phospho-PTEN (Thr383) Antibody (44-1062G) in IHC (P)

          Immunohistochemistry analysis of Phospho-PTEN (pThr383) showing staining in the cytoplasm and nucleus of paraffin-embedded human prostate carcinoma (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol ... View More {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          Phospho-PTEN (Thr383) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-PTEN (Thr383) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-PTEN (Thr383) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-PTEN (Thr383) Antibody in Western Blot (WB)
          Phospho-PTEN (Thr383) Polyclonal Antibody

          产品信息

          44-1062G

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50
          -
          产品规格

          种属反应

          Human, Mouse

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PTEN that contains threonine 383. The sequence is conserved in mouse and rat.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          纯化类型

          Antigen affinity chromatography

          保存液

          Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

          内含物

          0.05% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2533561

          靶标信息

          PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: Inositol polyphosphate 3-phosphatase; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin-like protein; phosphatidylinositol 3; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; pten tumor suppressor

          查看更多 收起

          基因别名: 10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN; PTEN1; TEP1

          查看更多 收起

          UniProt ID: (Human) P60484, (Mouse) O08586

          查看更多 收起

          Entrez Gene ID: (Human) 5728, (Mouse) 19211

          查看更多 收起

          功能
          magnesium ion binding phosphatidylinositol-3-phosphatase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity platelet-derived growth factor receptor binding protein binding protein tyrosine/serine/threonine phosphatase activity lipid binding anaphase-promoting complex binding phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity enzyme binding protein kinase binding PDZ domain binding identical protein binding inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity hydrolase activity phosphatase activity protein phosphatase
          参与通路
          regulation of cyclin-dependent protein serine/threonine kinase activity angiogenesis negative regulation of protein phosphorylation regulation of B cell apoptotic process protein dephosphorylation phosphatidylinositol biosynthetic process apoptotic process neuron-neuron synaptic transmission synapse assembly central nervous system development heart development aging response to nutrient learning or memory memory locomotory behavior cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation response to glucose response to zinc ion regulation of neuron projection development negative regulation of phosphatidylinositol 3-kinase signaling cell migration dentate gyrus development central nervous system neuron axonogenesis negative regulation of cell migration adult behavior negative regulation of myelination regulation of protein stability negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle regulation of synaptic transmission, GABAergic central nervous system myelin maintenance response to estradiol regulation of cellular component size regulation of myeloid cell apoptotic process response to ATP multicellular organismal response to stress social behavior peptidyl-tyrosine dephosphorylation response to drug maternal behavior negative regulation of apoptotic process protein kinase B signaling endothelial cell migration inositol phosphate metabolic process response to ethanol locomotor rhythm negative regulation of cell size negative regulation of organ growth response to arsenic-containing substance inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling regulation of axon regeneration cardiac muscle tissue development forebrain morphogenesis brain morphogenesis negative regulation of epithelial cell proliferation negative regulation of phagocytosis negative regulation of axonogenesis protein stabilization T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of focal adhesion assembly negative regulation of protein kinase B signaling rhythmic synaptic transmission canonical Wnt signaling pathway synapse maturation prepulse inhibition male mating behavior long-term synaptic potentiation long term synaptic depression prostate gland growth dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to hypoxia negative regulation of ribosome biogenesis negative regulation of cell aging negative regulation of excitatory postsynaptic potential presynaptic membrane assembly postsynaptic density assembly positive regulation of TRAIL-activated apoptotic signaling pathway positive regulation of ubiquitin protein ligase activity positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of G1/S transition of mitotic cell cycle positive regulation of excitatory postsynaptic potential negative regulation of synaptic vesicle clustering lipid metabolic process nervous system development dephosphorylation neuron projection development cellular response to decreased oxygen levels positive regulation of apoptotic process regulation of cell cycle positive regulation of apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.
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