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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Parkin Antibodies

          Invitrogen

          Phospho-Parkin (Ser378) Polyclonal Antibody

          3 篇参考文献
          查看其他27个Parkin抗体

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          说明书
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          Cite Phospho-Parkin (Ser378) Polyclonal Antibody

          • 抗体检测数据 (1)
          Phospho-Parkin (Ser378) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          Phospho-Parkin (Ser378) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 1

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          Phospho-Parkin (Ser378) Antibody (PA1-4735) in WB

          Western blot of Parkin in HEK293 cells transfected with Parkin wild type and Parkin S378 mutant showing the specific immunolabeling of a band at ~52 kDa corresponding to Phospho-Parkin (Ser378) polyclonal antibody (Product # PA1-4735). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          Phospho-Parkin (Ser378) Antibody in Western Blot (WB)
          Phospho-Parkin (Ser378) Polyclonal Antibody

          产品信息

          PA1-4735

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000
          查看3篇已发表文章 3篇已发表文章
          产品规格

          种属反应

          Human

          已发表种属

          Human

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser378 of human PARK2 conjugated to KLH
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.25 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          内含物

          no preservative

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_1090601

          靶标信息

          The precise function of Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: E3 ubiquitin ligase; E3 ubiquitin-protein ligase parkin; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; Parkin; parkin 2; Parkin isoform 1; Parkin RBR E3 ubiquitin-protein ligase; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin)

          查看更多 收起

          基因别名: AR-JP; LPRS2; PARK2; PDJ; PRKN

          查看更多 收起

          UniProt ID: (Human) O60260

          查看更多 收起

          Entrez Gene ID: (Human) 5071

          查看更多 收起

          功能
          transcription regulatory region sequence-specific DNA binding G-protein coupled receptor binding transcription factor activity, sequence-specific DNA binding actin binding ubiquitin-protein transferase activity protein binding beta-catenin binding zinc ion binding tubulin binding ligase activity SH3 domain binding enzyme binding kinase binding protein kinase binding PDZ domain binding Hsp70 protein binding heat shock protein binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding identical protein binding histone deacetylase binding ubiquitin binding phospholipase binding chaperone binding ubiquitin protein ligase activity cullin family protein binding ubiquitin protein ligase activity involved in ERAD pathway ubiquitin-specific protease binding F-box domain binding ubiquitin-protein ligase
          参与通路
          negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination mitochondrial fission mitophagy negative regulation of protein phosphorylation startle response transcription, DNA-templated protein monoubiquitination response to oxidative stress mitochondrion organization central nervous system development learning adult locomotory behavior proteasomal protein catabolic process regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of mitochondrial fusion negative regulation of mitochondrial fusion regulation of mitochondrion organization regulation of glucose metabolic process free ubiquitin chain polymerization regulation of dopamine secretion macroautophagy protein ubiquitination regulation of protein ubiquitination protein destabilization negative regulation of actin filament bundle assembly regulation of lipid transport positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of glucokinase activity cellular response to unfolded protein response to endoplasmic reticulum stress synaptic transmission, glutamatergic protein K29-linked ubiquitination ERAD pathway regulation of dopamine metabolic process norepinephrine metabolic process dopamine metabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA binding negative regulation of neuron apoptotic process cellular protein catabolic process cellular protein metabolic process protein K27-linked ubiquitination negative regulation by host of viral genome replication positive regulation of protein catabolic process positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of insulin secretion protein stabilization positive regulation of neurotransmitter uptake dopamine uptake involved in synaptic transmission protein autoubiquitination regulation of mitochondrial membrane potential zinc ion homeostasis negative regulation of cell death regulation of canonical Wnt signaling pathway parkin-mediated mitophagy in response to mitochondrial depolarization neuron cellular homeostasis protein K63-linked ubiquitination protein localization to mitochondrion aggresome assembly protein K48-linked ubiquitination protein K11-linked ubiquitination cellular response to manganese ion protein K6-linked ubiquitination negative regulation of canonical Wnt signaling pathway positive regulation of mitochondrial fission negative regulation of release of cytochrome c from mitochondria cellular response to toxic substance mitophagy in response to mitochondrial depolarization regulation of cellular response to oxidative stress negative regulation of neuron death positive regulation of proteasomal protein catabolic process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of primary amine oxidase activity positive regulation of protein linear polyubiquitination regulation of synaptic vesicle transport negative regulation of oxidative stress-induced cell death regulation of protein targeting to mitochondrion positive regulation of tumor necrosis factor-mediated signaling pathway cellular response to dopamine negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of dendrite extension negative regulation of spontaneous neurotransmitter secretion regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process
          It has to be done as per old AB suggested Products section.
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