Invitrogen

Phospho-Presenilin 1 (Ser310) Recombinant Rabbit Monoclonal Antibody (K01_3L08)

查看其他28个Presenilin 1抗体

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问题与答案

抗体检测数据 (1)

Phospho-Presenilin 1 (Ser310) Antibody in Western Blot (WB)

Phospho-Presenilin 1 (Ser310) Antibody in Western Blot (WB)

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Phospho-Presenilin 1 (Ser310) Antibody (MA564380) in WB

Western blot analysis of Phospho-Presenilin 1 (Ser310) in various lysates. Samples were incubated with Phospho-Presenilin 1 (Ser310) recombinant monoclonal (Product # MA564380). Samples: Jurkat, Hela lysates.

Phospho-Presenilin 1 (Ser310) Antibody in Western Blot (WB)

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Phospho-Presenilin 1 (Ser310) Antibody in Western Blot (WB) — Western blot analysis of Phospho-Presenilin 1 (Ser310) in various lysates. Samples were incubated with Phospho-Presenilin 1 (Ser310) recombinant monoclonal (Product # MA564380). Samples: Jurkat, Hela lysates.

Immunogen image

Phospho-Presenilin 1 (Ser310) Recombinant Rabbit Monoclonal Antibody (K01_3L08)

Immunogen Image Phospho-Presenilin 1 (Ser310) Recombinant Rabbit Monoclonal Antibody (K01_3L08)

产品信息

MA564380

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_3L08

抗原

A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol

内含物

0.01% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Alzheimer Disease 3; Minilin; Presenilin-1; presenilin1; Protein S182; PS-1; S182 protein; Senilin 1

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基因别名: AD3; FAD; PS-1; PS1; PSEN1; PSNL1; S182

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UniProt ID: (Human) P49768

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Entrez Gene ID: (Human) 5663

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endopeptidase activity aspartic-type endopeptidase activity calcium channel activity protein binding beta-catenin binding PDZ domain binding cadherin binding aspartic protease

autophagosome assembly negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity blood vessel development cell fate specification somitogenesis neuron migration positive regulation of receptor recycling heart looping hematopoietic progenitor cell differentiation T cell activation involved in immune response neural retina development protein glycosylation membrane protein ectodomain proteolysis mitochondrial transport cellular response to DNA damage stimulus response to oxidative stress negative regulation of epidermal growth factor-activated receptor activity Notch signaling pathway Notch receptor processing memory post-embryonic development protein transport L-glutamate transport choline transport synaptic vesicle targeting single organismal cell-cell adhesion protein processing cerebral cortex cell migration Cajal-Retzius cell differentiation dorsal/ventral neural tube patterning embryonic limb morphogenesis positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis beta-amyloid formation intracellular signal transduction regulation of phosphorylation amyloid precursor protein catabolic process myeloid dendritic cell differentiation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity regulation of protein binding positive regulation of MAP kinase activity negative regulation of neuron apoptotic process skin morphogenesis positive regulation of transcription, DNA-templated regulation of synaptic plasticity thymus development neuron development skeletal system morphogenesis brain morphogenesis epithelial cell proliferation negative regulation of axonogenesis positive regulation of coagulation T cell receptor signaling pathway neuron apoptotic process negative regulation of ubiquitin-protein transferase activity smooth endoplasmic reticulum calcium ion homeostasis regulation of synaptic transmission, glutamatergic canonical Wnt signaling pathway regulation of resting membrane potential positive regulation of dendritic spine development calcium ion transmembrane transport negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway