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Invitrogen
Phospho-RET (Tyr1062) Polyclonal Antibody
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Phospho-RET (Tyr1062) Antibody (PA5-78149) in WB
Western Blot using Phospho-RET (Tyr1062) Polyclonal Antibody (Product # PA5-78149). Untreated (–) and treated (+) K562 whole cell extracts (30 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with Phospho-RET (Tyr1062) Polyclonal Antibody (Product # PA5-78149) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody, and the signal was developed wi... View More
产品信息
PA5-78149
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide surrounding phospho Tyr1062 of human Ret. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.37 mg/mL
规格
137 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: K562
Predicted Reactivity: Mouse (100%), Rat (100%), Dog (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. RET transduce signals for cell growth and differentiation. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cadherin family member 12; Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); cadherin-related family member 16; EC 2.7.10.1; ELKS; Hydroxyaryl protein kinase; kinase Ret; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; OTTHUMP00000216967; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; ret; RET ELE1; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET receptor tyrosine kinase; unnamed protein product
基因别名: c-Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1; RET51; RET9
UniProt ID: (Human) P07949, (Mouse) P35546
Entrez Gene ID: (Human) 5979, (Mouse) 19713
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
calcium ion binding
protein binding
ATP binding
kinase activity
transferase activity
signaling receptor activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
MAPK cascade
ureteric bud development
neural crest cell migration
embryonic epithelial tube formation
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
neuron cell-cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
axon guidance
posterior midgut development
positive regulation of gene expression
positive regulation of neuron projection development
regulation of cell adhesion
neuron differentiation
positive regulation of cell migration
membrane protein proteolysis
positive regulation of cell adhesion mediated by integrin
ureter maturation
glial cell-derived neurotrophic factor receptor signaling pathway
neuron maturation
positive regulation of MAPK cascade
positive regulation of cell size
positive regulation of transcription, DNA-templated
response to pain
enteric nervous system development
regulation of axonogenesis
positive regulation of protein kinase B signaling
Peyer's patch morphogenesis
cellular response to retinoic acid
positive regulation of metanephric glomerulus development
lymphocyte migration into lymphoid organs
GDF15-GFRAL signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
anatomical structure morphogenesis
positive regulation of neuron maturation
phosphorylation
peptidyl-tyrosine phosphorylation
innervation
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