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Phospho-RUNX2 (Ser28) Polyclonal Antibody

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Phospho-RUNX2 (Ser28) Polyclonal Antibody

产品信息

PA5-105643

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-

免疫沉淀 (IP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human RUNX2(Accession Q13950), corresponding to amino acid residues around phosphorylated Ser28.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2817071

产品详细信息

Antibody detects endogenous levels of RUNX2 only when phosphorylated at S28.

靶标信息

RUNX2, a nuclear protein, is a member of the RUNX family of transcription factors and has an Runt DNA-binding domain. It is essential for membranous and endochondral bone formation. It not only regulates osteoblastic differentiation and skeletal morphogenesis but also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer and with more affinity, as a subunit of a heterodimeric complex. It plays a critical role in increasing TGFBR1 expression by osteoblasts and functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. Mutations lead to disorders in bone development like cleidocranial dysplasia (CCD).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Acute myeloid leukemia 3 protein; AKV core binding factor; AML-3; CBF-alpha-1; core binding factor alpha 1; Core-binding factor subunit alpha-1; core-binding factor, runt domain, alpha subunit 1; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2-alpha A; PEBP2 alpha A; PEBP2-alpha A; Polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt related transcription factor 2; Runt-related transcription factor 2; RUNX 2; RUNX-2; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit

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基因别名: AML3; Cbf; CBF-alpha-1; Cbfa-1; CBFA1; CCD; CCD1; CLCD; LS3; OSF-2; OSF2; PEA2aA; PEBP2A; Pebp2a1; PEBP2aA; Pebpa2a; RUNX2

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UniProt ID: (Human) Q13950, (Mouse) Q08775

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Entrez Gene ID: (Human) 860, (Rat) 367218, (Mouse) 12393

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功能
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding ATP binding protein domain specific binding chromatin DNA binding bHLH transcription factor binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor binding histone deacetylase binding transcription regulatory region DNA binding repressing transcription factor binding DNA-binding transcription factor immunoglobulin fold transcription factor Runt transcription factor gene-specific transcriptional regulator
参与通路
skeletal system development ossification osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte differentiation chondrocyte development osteoblast development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transmembrane receptor protein serine/threonine kinase signaling pathway smoothened signaling pathway cell proliferation positive regulation of cell proliferation gene expression regulation of gene expression positive regulation of gene expression hemopoiesis cell differentiation neuron differentiation T cell differentiation regulation of ossification bone mineralization BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis ligamentous ossification regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth regulation of cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation embryonic cranial skeleton morphogenesis skeletal system morphogenesis stem cell differentiation epithelial cell proliferation positive regulation of epithelial cell proliferation SMAD protein signal transduction stem cell proliferation response to sodium phosphate positive regulation of stem cell proliferation transcription, DNA-templated transcription from RNA polymerase II promoter cellular response to fibroblast growth factor stimulus positive regulation of ossification cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
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