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Invitrogen
Phospho-SREBP2 (Ser455) Polyclonal Antibody
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Phospho-SREBP2 (Ser455) Antibody (PA5-106042) in IHC (P)
Immunohistochemistry analysis of Phospho-SREBP2 (Ser455) in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-SREBP2 (Ser455) polyclonal antibody (Product # PA5-106042) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antib... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106042
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SREBF2(Accession Q12772), corresponding to amino acid residues around phosphorylated Ser455.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of SREBP2 only when phosphorylated at Ser455.
靶标信息
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bHLHd2; Class D basic helix-loop-helix protein 2; srebf2; srebf2 {ECO:0000312|EMBL:AAI01903.1}; SREBP-2; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2
基因别名: AI608257; BHLHD2; lop13; nuc; SREBF2; Srebf2_retired; SREBP-2; SREBP2; SREBP2gc
UniProt ID: (Rat) Q3T1I5, (Mouse) Q3U1N2
Entrez Gene ID: (Rat) 300095, (Mouse) 20788
C-8 sterol isomerase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein C-terminus binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity
E-box binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
spermatogenesis
aging
cholesterol metabolic process
lipid biosynthetic process
response to hormone
response to lead ion
positive regulation of cholesterol storage
response to lipid
response to drug
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to low-density lipoprotein particle
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of cholesterol efflux
regulation of cholesterol homeostasis
transcription from RNA polymerase II promoter
lipid metabolic process
steroid metabolic process
cellular response to starvation
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
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