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Fabgennix
Phospho-Smad1 (Ser453, Ser455) Polyclonal Antibody, FITC
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Product Details
PMAD-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 405-455 on D. melanogaster Mothers against dpp protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apang; CG12399-PA; CG12399-PB; DWFC; hSMAD1; JV5-1; Mad-PA; Mad-PB; MADH5; mother against decapentaplegic; mother against Dpp; mothers against decapentaplegi; mothers against decapentaplegic; Mothers-against-decapentaplegic; Mothers-against-DPP-related-1; OTTHUMP00000220456; phospho-Smad; phosphorylated smad; phosphoSmad; Protein mothers against dpp; RE72705p; SMAD; SMAD5
Gene Aliases: 2/23; apg; c28; CG12399; dMAD; Dmel\CG12399; Dmel_CG12399; E(zen)2; En(vvl); l(2)K00237; MAD; Mat; P-Mad; PMad; pSmad; Smad; Smad1
UniProt ID: (Fruit fly) P42003
Entrez Gene ID: (Fruit fly) 33529
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
ubiquitin protein ligase binding
sequence-specific DNA binding
I-SMAD binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
compound eye morphogenesis
transforming growth factor beta receptor signaling pathway
ventral cord development
imaginal disc-derived wing morphogenesis
imaginal disc-derived leg morphogenesis
histoblast morphogenesis
heart development
imaginal disc morphogenesis
imaginal disc-derived wing vein morphogenesis
anatomical structure morphogenesis
cell differentiation
BMP signaling pathway
ovarian follicle cell development
germ-line stem cell population maintenance
somatic stem cell population maintenance
trunk segmentation
germ-line stem cell division
R8 cell fate specification
regulation of cell differentiation
negative regulation of salivary gland boundary specification
positive regulation of synaptic growth at neuromuscular junction
positive regulation of transcription from RNA polymerase II promoter
wing disc anterior/posterior pattern formation
SMAD protein signal transduction
transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification
positive regulation of neuromuscular junction development
negative regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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