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Phospho-TAK1 (Thr184, Thr187) Monoclonal Antibody (K.846.3)

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Phospho-TAK1 (Thr184, Thr187) Monoclonal Antibody (K.846.3)

产品信息

MA5-15073

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
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免疫组化（冰冻） (IHC (F))

-
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

-
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流式细胞分析 (Flow)

-
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产品规格

种属反应

Human

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Monoclonal

类型

Antibody

克隆号

K.846.3

抗原

Phosphopeptide corresponding to residues surrounding pThr184 and pThr187 of human TAK1
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

24 µg/mL

纯化类型

Affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

<0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10982333

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: M3K7; Mitogen-activated protein kinase kinase kinase 7; RP1-154G14.1; TAK1d; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1; unnamed protein product

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基因别名: CSCF; FMD2; MAP3K7; MEKK7; TAK1; TGF1a

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UniProt ID: (Human) O43318

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Entrez Gene ID: (Human) 6885

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功能
nucleotide binding magnesium ion binding transcription coactivator binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase kinase activity receptor binding type II transforming growth factor beta receptor binding protein binding ATP binding MAP kinase kinase kinase kinase activity kinase activity transferase activity protein kinase binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone kinase activity identical protein binding metal ion binding scaffold protein binding protein serine kinase activity protein serine/threonine kinase binding DNA-binding transcription factor binding linear polyubiquitin binding
参与通路
MAPK cascade response to hypoxia stimulatory C-type lectin receptor signaling pathway positive regulation of T cell cytokine production cytoplasmic pattern recognition receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway chromatin remodeling apoptotic process inflammatory response immune response signal transduction transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation JNK cascade positive regulation of metabolic process positive regulation of autophagy negative regulation of gene expression positive regulation of macroautophagy signal transduction involved in regulation of gene expression SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of type I interferon production protein exit from endoplasmic reticulum positive regulation of interleukin-2 production toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway NIK/NF-kappaB signaling p38MAPK cascade Fc-epsilon receptor signaling pathway interleukin-33-mediated signaling pathway interleukin-17A-mediated signaling pathway defense response to bacterium signal transduction in response to DNA damage positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling anoikis positive regulation of MAPK cascade positive regulation of JUN kinase activity positive regulation of cell cycle positive regulation of cell size T cell receptor signaling pathway stress-activated MAPK cascade interleukin-1-mediated signaling pathway cellular response to tumor necrosis factor cellular response to hypoxia cellular response to transforming growth factor beta stimulus cGAS/STING signaling pathway positive regulation of cGAS/STING signaling pathway negative regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling cellular response to angiotensin positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration response to angiotensin
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