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Phospho-TAOK1/TAOK2/TAOK3 (Ser181, Ser177) Recombinant Rabbit Monoclonal Antibody (K01_4Q66)

查看其他3个TAOK1/TAOK2/TAOK3抗体

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Phospho-TAOK1/TAOK2/TAOK3 (Ser181, Ser177) Recombinant Rabbit Monoclonal Antibody (K01_4Q66)

产品信息

MA567642

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_4Q66

抗原

A synthesized peptide derived from human Phospho-TAOK1/2/3 (S181 + S181 + S177).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA, 150mM NaCl, 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

TAOK kinases, including TAOK1, TAOK2, and TAOK3, are serine-threonine kinases that belong to the sterile 20 (STE20) family and play significant roles in various cellular processes, including proliferation, apoptosis, and tumor progression. TAOK1 is implicated in neurodevelopmental disorders and has an evolving phenotype and genotype spectrum, which includes associations with macrocephaly and autism spectrum disorders. The TAOK2 gene, located on chromosome 16, is a crucial kinase participating in the regulation of protein translation through the phosphorylation of eukaryotic elongation factor 2 (eEF2) and is also involved in neurodevelopmental pathways. Moreover, TAOK2 acts as a potential tumor suppressor, with its downregulation linked to cancer progression in numerous types of cancer. TAOK3, another member of this kinase family, is expressed ubiquitously and has been linked to the regulation of age-associated inflammation, acting through pathways that limit pro-inflammatory monocyte accumulation. Additionally, TAOK3 is involved in osteoblast differentiation and modulates T cell receptor signaling by influencing components like SHP-1 and LCK. All three kinases are crucial for maintaining cellular homeostasis and their aberrations can lead to pathological conditions, particularly related to neurodevelopment and cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Axotomy-related gene 357 protein; CTCL-associated antigen HD-CL-09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; hKFC-A; hKFC-B; hKFC-C; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; Kinase from chicken homolog B; Kinase from chicken homolog C; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 1; Prostate-derived sterile 20-like kinase 2; protein kinase homolog; PSK-1; PSK-2; serine-threonine kinase; serine/threonine protein kinase TAO1; serine/threonine protein kinase TAO1 homolog; serine/threonine protein kinase TAO2; Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase TAO3; STE20-like kinase; STE20-like kinase PSK2; TAO kinase 2TAO kinase 2; TAOK1; Thousand and one amino acid protein 1; Thousand and one amino acid protein 2; Thousand and one amino acid protein 3; Thousand and one amino acid protein kinase 1; Thousand and one amino acid protein kinase 2; unnamed protein product

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基因别名: 1110033K02Rik; 2810468K05Rik; 2900006A08Rik; A130052D22; A430105I05Rik; Arg357; AU020252; B230344N16; D130018F14Rik; DDIB; DPK; hKFC-A; hKFC-B; hTAOK1; JIK; KDS; KFC-B; KIAA0881; KIAA1361; MAP3K16; MAP3K17; MAP3K18; MARKK; mKIAA0881; mKIAA1361; PSK; PSK-2; PSK1; PSK1-BETA; PSK2; TAO1; TAO2; Tao2beta; TAOK1; TAOK2; TAOK3; UNQ2971/PRO7431

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UniProt ID: (Human) Q7L7X3, (Human) Q9UL54, (Human) Q9H2K8, (Mouse) Q5F2E8, (Rat) O88664, (Mouse) Q6ZQ29, (Rat) Q9JLS3, (Mouse) Q8BYC6, (Rat) Q53UA7

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Entrez Gene ID: (Human) 57551, (Human) 9344, (Human) 51347, (Mouse) 216965, (Rat) 286993, (Mouse) 381921, (Rat) 64666, (Mouse) 330177, (Rat) 304530

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功能
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity alpha-tubulin binding protein serine/threonine kinase activator activity tau protein binding beta-tubulin binding tau-protein kinase activity protein serine kinase activity MAP kinase kinase kinase activity mitogen-activated protein kinase kinase binding neuropilin binding protein kinase inhibitor activity transferase activity, transferring phosphorus-containing groups protein kinase binding protein kinase activator activity non-receptor serine/threonine protein kinase
参与通路
microtubule cytoskeleton organization DNA repair apoptotic process cellular response to DNA damage stimulus negative regulation of microtubule depolymerization mitotic G2 DNA damage checkpoint central nervous system neuron development positive regulation of stress-activated MAPK cascade regulation of actin cytoskeleton organization positive regulation of JNK cascade regulation of cytoskeleton organization neuron cellular homeostasis regulation of microtubule cytoskeleton organization execution phase of apoptosis regulation of cell growth protein targeting to membrane axonogenesis regulation of cell shape cell migration actin cytoskeleton organization positive regulation of MAPK cascade focal adhesion assembly cell morphogenesis involved in neuron differentiation neuron projection morphogenesis stress-activated MAPK cascade basal dendrite morphogenesis basal dendrite arborization MAPK cascade protein phosphorylation regulation of MAPK cascade positive regulation of JUN kinase activity negative regulation of JNK cascade activation of MAPKK activity regulation of mitotic cell cycle phosphorylation signal transduction by protein phosphorylation stress-activated protein kinase signaling cascade G2 DNA damage checkpoint regulation of apoptotic process intracellular signal transduction positive regulation of protein kinase activity response to stress protein autophosphorylation
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