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Abnova
Phospho-TAOK1/TAOK2/TAOK3 (Ser181, Ser181, Ser177) Recombinant Rabbit Monoclonal Antibody
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产品信息
RAB01773
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1.
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
TAOK kinases, including TAOK1, TAOK2, and TAOK3, are serine-threonine kinases that belong to the sterile 20 (STE20) family and play significant roles in various cellular processes, including proliferation, apoptosis, and tumor progression. TAOK1 is implicated in neurodevelopmental disorders and has an evolving phenotype and genotype spectrum, which includes associations with macrocephaly and autism spectrum disorders. The TAOK2 gene, located on chromosome 16, is a crucial kinase participating in the regulation of protein translation through the phosphorylation of eukaryotic elongation factor 2 (eEF2) and is also involved in neurodevelopmental pathways. Moreover, TAOK2 acts as a potential tumor suppressor, with its downregulation linked to cancer progression in numerous types of cancer. TAOK3, another member of this kinase family, is expressed ubiquitously and has been linked to the regulation of age-associated inflammation, acting through pathways that limit pro-inflammatory monocyte accumulation. Additionally, TAOK3 is involved in osteoblast differentiation and modulates T cell receptor signaling by influencing components like SHP-1 and LCK. All three kinases are crucial for maintaining cellular homeostasis and their aberrations can lead to pathological conditions, particularly related to neurodevelopment and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Axotomy-related gene 357 protein; CTCL-associated antigen HD-CL-09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; hKFC-A; hKFC-B; hKFC-C; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; Kinase from chicken homolog B; Kinase from chicken homolog C; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 1; Prostate-derived sterile 20-like kinase 2; PSK-1; PSK-2; serine-threonine kinase; serine/threonine protein kinase TAO1; serine/threonine protein kinase TAO1 homolog; serine/threonine protein kinase TAO2; Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase TAO3; STE20-like kinase; STE20-like kinase PSK2; TAO kinase 2TAO kinase 2; TAOK1; Thousand and one amino acid protein 1; Thousand and one amino acid protein 2; Thousand and one amino acid protein 3; Thousand and one amino acid protein kinase 1; Thousand and one amino acid protein kinase 2
基因别名: 1110033K02Rik; 2810468K05Rik; 2900006A08Rik; A130052D22; A430105I05Rik; Arg357; AU020252; B230344N16; D130018F14Rik; DPK; hKFC-B; hTAOK1; JIK; KDS; KFC-B; KIAA0881; KIAA1361; MAP3K16; MAP3K17; MAP3K18; MARKK; mKIAA0881; mKIAA1361; PSK; PSK-2; PSK1; PSK1-BETA; PSK2; TAO1; TAO2; TAOK1; TAOK2; TAOK3; UNQ2971/PRO7431
UniProt ID: (Human) Q7L7X3, (Human) Q9UL54, (Human) Q9H2K8, (Mouse) Q5F2E8, (Rat) O88664, (Mouse) Q6ZQ29, (Rat) Q9JLS3, (Mouse) Q8BYC6, (Rat) Q53UA7
Entrez Gene ID: (Human) 57551, (Human) 9344, (Human) 51347, (Mouse) 216965, (Rat) 286993, (Mouse) 381921, (Rat) 64666, (Mouse) 330177, (Rat) 304530
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
mitogen-activated protein kinase kinase binding
protein kinase inhibitor activity
nucleotide binding
MAP kinase kinase kinase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
protein kinase activator activity
non-receptor serine/threonine protein kinase
DNA repair
protein phosphorylation
cellular response to DNA damage stimulus
sister chromatid cohesion
signal transduction by protein phosphorylation
G2 DNA damage checkpoint
spindle checkpoint
positive regulation of stress-activated MAPK cascade
positive regulation of JNK cascade
regulation of cytoskeleton organization
execution phase of apoptosis
activation of MAPKK activity
regulation of cell growth
protein targeting to membrane
apoptotic process
response to stress
regulation of cell shape
cell migration
actin cytoskeleton organization
focal adhesion assembly
stress-activated MAPK cascade
MAPK cascade
negative regulation of protein kinase activity
mitotic G2 DNA damage checkpoint
positive regulation of JUN kinase activity
negative regulation of JNK cascade
protein autophosphorylation
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
intracellular signal transduction
positive regulation of protein kinase activity
