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Invitrogen
Phospho-TGFBR2 (Ser553) Polyclonal Antibody
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Phospho-TGFBR2 (Ser553) Antibody (PA5-114663) in ICC/IF
Immunocytochemistry analysis of Phospho-TGFBR2 (Ser553) in HeLa cells (heat shock treatment). Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114663). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conj... View More
产品信息
PA5-114663
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TGFBR2 around the phosphorylation site of Ser553.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of TGFBR2 only when phosphorylated at Ser553.
靶标信息
Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: tbetaR-II; tgf beta receptor 2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type IIB; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFR-2; TGFR2; transforming growth factor beta receptor II; transforming growth factor beta receptor type II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; Transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor
基因别名: 1110020H15Rik; AAT3; AU042018; DNIIR; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; RIIDN; TAAD2; TbetaR-II; TbetaRII; TBR-II; TGF-beta 2; TGFbeta-RII; TGFBR2; Tgfbr2T; TGFR-2
UniProt ID: (Human) P37173, (Rat) P38438, (Mouse) Q62312
Entrez Gene ID: (Human) 7048, (Rat) 81810, (Mouse) 21813
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
glycosaminoglycan binding
mitogen-activated protein kinase kinase kinase binding
type I transforming growth factor beta receptor binding
SMAD binding
metal ion binding
transforming growth factor beta binding
type III transforming growth factor beta receptor binding
protein homodimerization activity
protein heterodimerization activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
blood vessel development
patterning of blood vessels
vasculogenesis
in utero embryonic development
heart looping
positive regulation of mesenchymal cell proliferation
lens development in camera-type eye
positive regulation of tolerance induction to self antigen
positive regulation of B cell tolerance induction
positive regulation of T cell tolerance induction
outflow tract morphogenesis
growth plate cartilage chondrocyte growth
protein phosphorylation
receptor-mediated endocytosis
apoptotic process
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
Notch signaling pathway
smoothened signaling pathway
gastrulation
brain development
heart development
embryo implantation
aging
response to nutrient
positive regulation of cell proliferation
response to mechanical stimulus
response to glucose
regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of epithelial to mesenchymal transition
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
negative regulation of transforming growth factor beta receptor signaling pathway
organ regeneration
activation of protein kinase activity
embryonic hemopoiesis
wound healing
regulation of cell proliferation
response to drug
myeloid dendritic cell differentiation
positive regulation of skeletal muscle tissue regeneration
response to estrogen
positive regulation of angiogenesis
response to steroid hormone
digestive tract development
positive regulation of smooth muscle cell proliferation
embryonic cranial skeleton morphogenesis
positive regulation of NK T cell differentiation
palate development
negative regulation of cardiac muscle cell proliferation
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
bronchus morphogenesis
trachea formation
mammary gland morphogenesis
lung lobe morphogenesis
response to cholesterol
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
lens fiber cell apoptotic process
positive regulation of reactive oxygen species metabolic process
response to hypoxia
growth plate cartilage development
transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cell proliferation
organ morphogenesis
response to organic substance
response to organic cyclic compound
lung development
cartilage development
lung morphogenesis
bronchus development
trachea morphogenesis
phosphorylation
cell differentiation
regulation of growth
