Invitrogen

Phospho-TRAP220 (Thr1032) Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
Phospho-TRAP220 (Thr1032) Polyclonal Antibody

产品信息

PA5-106026

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human MED1(Accession Q15648), corresponding to amino acid residues around phosphorylated Thr1032.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2817425

产品详细信息

Antibody detects endogenous levels of TRAP220/MED1 only when phosphorylated at Thr1032.

靶标信息

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Mediator of RNA polymerase II transcription subunit 1; p53 regulatory protein RB18A; PBP; peroxisome proliferator activated receptor binding protein; Peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPAR-binding protein; PPARG binding protein; PPRB; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; Thyroid receptor-interacting protein 2; TR-interacting protein 2; Trap220; TRIP-2; vitamin D receptor-interacting protein 230 kD; Vitamin D receptor-interacting protein complex component DRIP205

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基因别名: AI480703; ARC205; CRSP1; CRSP200; CRSP210; DRIP205; DRIP230; l11Jus15; MED1; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2

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UniProt ID: (Human) Q15648, (Mouse) Q925J9

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Entrez Gene ID: (Human) 5469, (Mouse) 19014

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter binding RNA polymerase II transcription cofactor activity chromatin binding transcription cofactor activity transcription coactivator activity receptor activity protein binding transcription factor binding ligand-dependent nuclear receptor binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity thyroid hormone receptor coactivator activity chromatin DNA binding nuclear hormone receptor binding mediator complex binding vitamin D receptor binding retinoic acid receptor binding peroxisome proliferator activated receptor binding thyroid hormone receptor binding LBD domain binding ubiquitin protein ligase activity DNA binding protein complex binding RNA metabolism protein nucleic acid metabolism protein general transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis angiogenesis liver development embryonic placenta development lens development in camera-type eye thyroid hormone mediated signaling pathway ventricular trabecula myocardium morphogenesis retinal pigment epithelium development regulation of transcription from RNA polymerase I promoter transcription initiation from RNA polymerase II promoter thyroid hormone generation androgen biosynthetic process brain development lactation positive regulation of gene expression negative regulation of keratinocyte proliferation protein ubiquitination keratinocyte differentiation monocyte differentiation intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway organ regeneration positive regulation of intracellular estrogen receptor signaling pathway positive regulation of protein import into nucleus, translocation positive regulation of mammary gland epithelial cell proliferation embryonic heart tube development embryonic hindlimb morphogenesis embryonic hemopoiesis peroxisome proliferator activated receptor signaling pathway cellular response to hepatocyte growth factor stimulus megakaryocyte development mRNA transcription from RNA polymerase II promoter negative regulation of apoptotic process cellular lipid metabolic process fat cell differentiation positive regulation of keratinocyte differentiation positive regulation of erythrocyte differentiation negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter erythrocyte development enucleate erythrocyte development regulation of cell cycle positive regulation of interferon-gamma-mediated signaling pathway mammary gland branching involved in thelarche mammary gland branching involved in pregnancy epithelial cell proliferation involved in mammary gland duct elongation positive regulation of G0 to G1 transition ERK1 and ERK2 cascade regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus cellular response to steroid hormone stimulus cellular response to thyroid hormone stimulus positive regulation of receptor activity positive regulation of hepatocyte proliferation regulation of RNA biosynthetic process in utero embryonic development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development heart development positive regulation of cell proliferation organ morphogenesis mammary gland epithelial cell proliferation camera-type eye development
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