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Phospho-TrkA/TrkB (Tyr674, Tyr675, Tyr706, Tyr707) Monoclonal Antibody (C.795.3)

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Phospho-TrkA/TrkB (Tyr674, Tyr675, Tyr706, Tyr707) Monoclonal Antibody (C.795.3)

产品信息

MA5-14927

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫沉淀 (IP)

1:50
-
产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Monoclonal

类型

Antibody

克隆号

C.795.3

抗原

Synthetic phosphopeptide corresponding to residues surrounding pTyr674/675 of human TrkA
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

36 µg/mL

规格

3.6 µg

纯化类型

Affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

<0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10986069

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: BDNF-tropomyosine receptor kinase B; gp140trk; GP145-TrkB/GP95-TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK2; Oncogene TRK; p140-TrkA; slow nerve growth factor receptor; trk tyrosine-specific protein kinase; trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB; trkB tyrosine kinase; TrkB-T-Shc; trkB.T1; tropomyosin receptor kinase A; tropomyosin-related kinase A; tropomyosin-related kinase B; truncated trkB; tyrosine kinase receptor A; tyrosine kinase receptor B; unnamed protein product

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基因别名: DEE58; EIEE58; GP145-TrkB; MTC; OBHD; p140-TrkA; RATTRKB1; Tkrb; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKB1

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UniProt ID: (Human) P04629, (Human) Q16620, (Rat) P35739, (Rat) Q63604

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Entrez Gene ID: (Human) 4914, (Human) 4915, (Rat) 59109, (Rat) 25054

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功能
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase binding identical protein binding protein homodimerization activity neurotrophin binding nerve growth factor binding protease binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity transmembrane receptor protein serine/threonine kinase activity receptor tyrosine kinase binding
参与通路
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway spermatogenesis nervous system development axon guidance learning or memory circadian rhythm negative regulation of cell proliferation response to xenobiotic stimulus programmed cell death involved in cell development positive regulation of neuron projection development peptidyl-tyrosine phosphorylation olfactory nerve development nerve development B cell differentiation neuron projection development response to nutrient levels response to nicotine peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway mechanoreceptor differentiation positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway sympathetic nervous system development neuron development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain response to hydrostatic pressure response to electrical stimulus positive regulation of protein kinase B signaling positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to growth factor stimulus cellular response to beta-amyloid cellular response to nerve growth factor stimulus neuron migration learning positive regulation of cell proliferation positive regulation of gene expression central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway neurotrophin signaling pathway regulation of GTPase activity positive regulation of MAPK cascade oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of protein kinase B signaling long-term synaptic potentiation trans-synaptic signaling by BDNF, modulating synaptic transmission negative regulation of beta-amyloid formation cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis negative regulation of apoptotic process vasculogenesis neuromuscular junction development long-term memory feeding behavior response to light stimulus regulation of neuron projection development response to auditory stimulus glutamate secretion neuronal action potential propagation myelination in peripheral nervous system positive regulation of cell projection organization positive regulation of peptidyl-serine phosphorylation regulation of MAPK cascade response to ethanol retinal rod cell development regulation of neurotransmitter secretion regulation of synaptic plasticity regulation of dendrite development positive regulation of synaptic transmission regulation of cytosolic calcium ion concentration positive regulation of nervous system development retina development in camera-type eye cellular response to amino acid stimulus cellular response to tumor necrosis factor positive regulation of long term synaptic depression positive regulation of glucocorticoid receptor signaling pathway positive regulation of excitatory postsynaptic potential
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