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Phospho-TrkA/TrkB (Tyr785, Tyr816) Polyclonal Antibody
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Phospho-TrkA/TrkB (Tyr785, Tyr816) Antibody (PA5-105133) in ICC/IF
Immunocytochemistry analysis of Phospho-TrkA/TrkB (Tyr785, Tyr816) in Hela cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-TrkA/TrkB (Tyr785, Tyr816) polyclonal antibody (Product # PA5-105133) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conj... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105133
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NTRK1(Accession P04629), corresponding to amino acid residues around phosphorylated Tyr785.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of TrkA /TrkB only when phosphorylated at Tyr785.
靶标信息
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BDNF-tropomyosine receptor kinase B; gp140trk; GP145-TrkB/GP95-TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK2; Oncogene TRK; p140-TrkA; slow nerve growth factor receptor; trk tyrosine-specific protein kinase; trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB; trkB tyrosine kinase; TrkB-T-Shc; trkB.T1; tropomyosin receptor kinase A; tropomyosin-related kinase A; tropomyosin-related kinase B; truncated trkB; tyrosine kinase receptor A; tyrosine kinase receptor B; tyrosine protein kinase B (trkB) precursor; unnamed protein product
基因别名: DEE58; EIEE58; GP145-TrkB; GP145-TrkB/GP95-TrkB; MTC; OBHD; p140-TrkA; RATTRKB1; Tkr; Tkrb; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKB1
UniProt ID: (Human) P04629, (Human) Q16620, (Rat) P35739, (Mouse) Q3UFB7, (Mouse) P15209, (Rat) Q63604
Entrez Gene ID: (Human) 4914, (Human) 4915, (Rat) 59109, (Mouse) 18211, (Mouse) 18212, (Rat) 25054
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
GPI-linked ephrin receptor activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase binding
identical protein binding
protein homodimerization activity
neurotrophin binding
nerve growth factor binding
protease binding
brain-derived neurotrophic factor binding
brain-derived neurotrophic factor-activated receptor activity
transmembrane receptor protein serine/threonine kinase activity
receptor tyrosine kinase binding
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
spermatogenesis
nervous system development
axon guidance
learning or memory
circadian rhythm
negative regulation of cell proliferation
response to xenobiotic stimulus
programmed cell death involved in cell development
positive regulation of neuron projection development
peptidyl-tyrosine phosphorylation
olfactory nerve development
nerve development
B cell differentiation
neuron projection development
response to nutrient levels
response to nicotine
peptidyl-tyrosine autophosphorylation
nerve growth factor signaling pathway
mechanoreceptor differentiation
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
positive regulation of angiogenesis
positive regulation of Ras protein signal transduction
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
sympathetic nervous system development
neuron development
response to axon injury
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
response to hydrostatic pressure
response to electrical stimulus
positive regulation of protein kinase B signaling
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
innervation
axonogenesis involved in innervation
behavioral response to formalin induced pain
positive regulation of ERK1 and ERK2 cascade
cellular response to nicotine
cellular response to growth factor stimulus
cellular response to beta-amyloid
cellular response to nerve growth factor stimulus
response to activity
neuron migration
learning
positive regulation of cell proliferation
positive regulation of gene expression
central nervous system neuron development
cerebral cortex development
neuron differentiation
brain-derived neurotrophic factor receptor signaling pathway
neurotrophin signaling pathway
regulation of GTPase activity
positive regulation of MAPK cascade
oligodendrocyte differentiation
peripheral nervous system neuron development
positive regulation of axonogenesis
regulation of protein kinase B signaling
long-term synaptic potentiation
trans-synaptic signaling by BDNF, modulating synaptic transmission
negative regulation of beta-amyloid formation
cellular response to brain-derived neurotrophic factor stimulus
negative regulation of anoikis
vasculogenesis
neuromuscular junction development
long-term memory
feeding behavior
regulation of neuron projection development
glutamate secretion
neuronal action potential propagation
myelination in peripheral nervous system
positive regulation of cell projection organization
positive regulation of peptidyl-serine phosphorylation
negative regulation of apoptotic process
regulation of MAPK cascade
retinal rod cell development
regulation of neurotransmitter secretion
regulation of synaptic plasticity
regulation of dendrite development
positive regulation of synaptic transmission
regulation of cytosolic calcium ion concentration
positive regulation of nervous system development
retina development in camera-type eye
cellular response to amino acid stimulus
positive regulation of long term synaptic depression
positive regulation of glucocorticoid receptor signaling pathway
positive regulation of excitatory postsynaptic potential
response to light stimulus
response to auditory stimulus
response to ethanol
cellular response to tumor necrosis factor
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