Search
Invitrogen
Phospho-ZAK (Ser165) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 2
Phospho-ZAK (Ser165) Antibody (PA5-105924) in ICC/IF
Immunocytochemistry analysis of Phospho-ZAK (Ser165) in A549 cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-ZAK (Ser165) polyclonal antibody (Product # PA5-105924) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105924
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MAP3K20(Accession Q9NYL2), corresponding to amino acid residues around phosphorylated Ser165.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of ZAK only when phosphorylated at Ser165.
靶标信息
ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: HCCS-4; human cervical cancer suppressor gene 4 protein; leucine zipper- and sterile alpha motif kinase ZAK; leucine zipper- and sterile alpha motif-containing kinase; mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; mixed lineage kinase-related kinase; mixed lineage kinase-related kinase MRK-beta; MLK; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; protein kinase; sterile alpha motif and leucine zipper containing kinase AZK; unnamed protein product; ZAK1 homolog, leucine zipper and sterile-alpha motif kinase
基因别名: AZK; B230120H23Rik; CNM6; HCCS-4; MLK7; mlklak; MLT; MLTK; MLTKalpha; MLTKbeta; MRK; pk; RGD1561394; SFMMP; ZAK
UniProt ID: (Human) Q9NYL2, (Mouse) Q9ESL4
Entrez Gene ID: (Human) 51776, (Mouse) 65964, (Rat) 311743
magnesium ion binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
protein kinase activator activity
ribosome binding
small ribosomal subunit rRNA binding
protein serine kinase activity
stalled ribosome sensor activity
protein kinase regulator activity
DNA damage checkpoint
MAPK cascade
translational initiation
protein phosphorylation
inflammatory response
cytoskeleton organization
JNK cascade
stress-activated protein kinase signaling cascade
intracellular signal transduction
p38MAPK cascade
embryonic digit morphogenesis
positive regulation of apoptotic process
positive regulation of programmed cell death
protein autophosphorylation
stress-activated MAPK cascade
protein maturation
limb development
pyroptosis
negative regulation of stress-activated protein kinase signaling cascade
cellular response to gamma radiation
cellular response to UV-B
GCN2-mediated signaling
negative regulation of translation in response to endoplasmic reticulum stress
positive regulation of mitotic DNA damage checkpoint
NLRP1 inflammasome complex assembly
chromosome segregation
cell death
regulation of mitotic metaphase/anaphase transition
cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
