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Phospho-ZAP70/Syk (Tyr319, Tyr352) Recombinant Rabbit Monoclonal Antibody (Zap70Y319-A11)

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产品信息

MA5-37009

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-1,000 ng/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

Zap70Y319-A11

抗原

A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

规格

10 µg

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2896944

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

ZAP70 and SYK are closely related cytoplasmic tyrosine kinases that play central roles in immune receptor signaling. ZAP70 (Zeta-chain-associated protein kinase 70; gene: ZAP70) is primarily expressed in T lymphocytes and natural killer (NK) cells, where it is recruited to the T cell receptor (TCR) complex following antigen recognition. Upon activation, ZAP70 phosphorylates downstream adaptor proteins and initiates signaling cascades that drive T cell activation, proliferation, and differentiation. SYK (Spleen Tyrosine Kinase; gene: SYK) is predominantly expressed in B cells and other hematopoietic cells and functions analogously in B cell receptor (BCR) signaling, as well as in Fc receptor and integrin-mediated pathways. Although ZAP70 and SYK share structural homology and overlapping signaling mechanisms, they exhibit distinct expression patterns and immunological roles. Dysregulation of either kinase has been implicated in autoimmune disease, immunodeficiency, and hematologic malignancies, making them important targets in immunology and therapeutic research.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; p72-Syk; Spleen tyrosine kinase; Syk kinase; Syk-related kinase; Syk-related tyrosine kinase; TCR-associated protein tyrosine kinase; Tyrosine-protein kinase SYK; Tyrosine-protein kinase ZAP-70; unnamed protein product; ZAP-70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD

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基因别名: ADMIO2; IMD48; IMD82; p72-Syk; SRK; STCD; STD; SYK; TZK; ZAP-70; ZAP70

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UniProt ID: (Human) P43405, (Human) P43403

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Entrez Gene ID: (Human) 6850, (Human) 7535

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功能
nucleotide binding phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding integrin binding protein binding ATP binding interleukin-15 receptor binding kinase activity transferase activity protein kinase binding phosphatase binding Toll-like receptor binding SH2 domain binding phospholipase binding scaffold protein binding
参与通路
autophagosome assembly angiogenesis cell activation positive regulation of cytokine production serotonin secretion lymph vessel development positive regulation of receptor internalization stimulatory C-type lectin receptor signaling pathway adaptive immune response macrophage activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response immune system process serotonin secretion by platelet cell surface pattern recognition receptor signaling pathway negative regulation of inflammatory response to antigenic stimulus protein phosphorylation protein import into nucleus leukocyte cell-cell adhesion cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway integrin-mediated signaling pathway organ morphogenesis negative regulation of autophagy positive regulation of autophagy regulation of platelet activation regulation of tumor necrosis factor-mediated signaling pathway peptidyl-tyrosine phosphorylation leukotriene biosynthetic process calcium-mediated signaling platelet activation B cell differentiation neutrophil chemotaxis positive regulation of protein complex assembly receptor internalization cellular response to nutrient levels positive regulation of type I interferon production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-3 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of mast cell cytokine production regulation of superoxide anion generation positive regulation of superoxide anion generation positive regulation of cell adhesion mediated by integrin intracellular signal transduction collagen-activated tyrosine kinase receptor signaling pathway Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis interleukin-3-mediated signaling pathway TORC1 signaling gamma-delta T cell differentiation defense response to bacterium mast cell degranulation positive regulation of mast cell degranulation regulation of neutrophil degranulation beta selection positive regulation of MAPK cascade innate immune response positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation positive regulation of bone resorption positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation blood vessel morphogenesis regulation of phagocytosis regulation of immune response positive regulation of calcium-mediated signaling B cell receptor signaling pathway leukocyte migration regulation of sequence-specific DNA binding transcription factor activity establishment of localization in cell regulation of ERK1 and ERK2 cascade cellular response to molecule of fungal origin cellular response to lipid cellular response to low-density lipoprotein particle stimulus positive regulation of monocyte chemotactic protein-1 production regulation of arachidonic acid secretion regulation of platelet aggregation apoptotic signaling pathway beta-amyloid clearance positive regulation of cold-induced thermogenesis negative regulation of TORC1 signaling positive regulation of TORC1 signaling cellular response to beta-amyloid cellular response to lectin immune response T cell differentiation T cell activation B cell activation positive thymic T cell selection negative thymic T cell selection thymic T cell selection positive regulation of T cell differentiation alpha-beta T cell differentiation T cell receptor signaling pathway T cell aggregation T cell migration
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