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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • beta Catenin Antibodies

          Invitrogen

          Phospho-beta Catenin (Ser675) Polyclonal Antibody

          高级验证
          查看其他126个beta Catenin抗体

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          Cite Phospho-beta Catenin (Ser675) Polyclonal Antibody

          • 抗体检测数据 (2)
          • 高级验证 (1)
          Phospho-beta Catenin (Ser675) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          Phospho-beta Catenin (Ser675) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 3

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          Phospho-beta Catenin (Ser675) Antibody (PA5-97403) in WB

          Western blot was performed using Anti-Phospho-beta Catenin (Ser675) Polyclonal Antibody (Product # PA5-97403) and a 85 kDa band corresponding to Catenin beta-1 (Ser675) was observed across the cell lines tested and increased upon treatment with Human recombinant EGF and further increased upon MG132 treatment along with EGF. Whole cell extracts (30 µg lysate) of A-431 (Lane 1), A-431 treated with 100 ng/mL o... View More {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          Phospho-beta Catenin (Ser675) Antibody in Western Blot (WB)
          Phospho-beta Catenin (Ser675) Antibody in Western Blot (WB)
          Phospho-beta Catenin (Ser675) Antibody
          Phospho-beta Catenin (Ser675) Polyclonal Antibody

          产品信息

          PA5-97403

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:2,000
          -

          酶联免疫吸附实验 (ELISA)

          1 µg/mL
          -
          产品规格

          种属反应

          Human, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic peptide.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.36 mg/mL

          纯化类型

          Affinity Chromatography

          保存液

          PBS, pH 7.3, with 50% glycerol

          内含物

          0.05% ProClin 300

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2809205

          产品详细信息

          Immunogen sequence: RLSVE; Positive Samples: C6; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Nucleus, adherens junction, centrosome, cytoskeleton, microtubule organizing center, spindle pole

          靶标信息

          Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          引用该产品

          生物信息学

          蛋白别名: Bcatenin; beta 1 88kDa; Beta-catenin; Betacatenin; C20orf33; Cadherin associated protein; catenin; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; catenin beta; Catenin beta-1; Catenin beta1; Catenin β 1; Catenin β1; CTNB1; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; NAP; NYD-SP19; OTTHUMP00000209289; P14L; PP8304; RP5-1118M15.1; β catenin; βcatenin

          查看更多 收起

          基因别名: armadillo; Catnb; CTNNB; CTNNB1; MRD19; OK/SW-cl.35; PRO2286

          查看更多 收起

          UniProt ID: (Human) P35222, (Rat) Q9WU82

          查看更多 收起

          Entrez Gene ID: (Human) 1499, (Rat) 84353

          查看更多 收起

          功能
          RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity signal transducer activity protein binding protein C-terminus binding transcription factor binding enzyme binding kinase binding protein kinase binding protein phosphatase binding estrogen receptor binding protein complex binding ionotropic glutamate receptor binding nuclear hormone receptor binding transcription regulatory region DNA binding ion channel binding alpha-catenin binding cadherin binding SMAD binding androgen receptor binding nitric-oxide synthase binding I-SMAD binding repressing transcription factor binding cadherin binding involved in cell-cell adhesion euchromatin binding DNA binding chromatin binding R-SMAD binding
          参与通路
          negative regulation of transcription from RNA polymerase II promoter embryonic axis specification cell morphogenesis involved in differentiation skeletal system development patterning of blood vessels vasculogenesis branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second endoderm formation cell fate specification cell fate determination endodermal cell fate commitment neuron migration kidney development neural plate development liver development vasculature development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation lens morphogenesis in camera-type eye regulation of secondary heart field cardioblast proliferation mesenchymal to epithelial transition involved in metanephros morphogenesis metanephros morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell adhesion cell-matrix adhesion chemical synaptic transmission ectoderm development glial cell fate determination midgut development heart development cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation response to hormone anterior/posterior axis specification dorsal/ventral axis specification dorsal/ventral pattern formation proximal/distal pattern formation cellular process regulation of gene expression positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Schwann cell proliferation response to organic cyclic compound Wnt signaling pathway morphogenesis of embryonic epithelium single organismal cell-cell adhesion layer formation in cerebral cortex central nervous system vasculogenesis hair cycle process hemopoiesis cell differentiation T cell differentiation osteoclast differentiation lung development male genitalia development regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation forebrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis regulation of myelination positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol T cell differentiation in thymus negative regulation of protein sumoylation response to cytokine adherens junction organization adherens junction assembly protein localization to cell surface cellular protein localization embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic skeletal limb joint morphogenesis regulation of cell proliferation regulation of T cell proliferation odontogenesis of dentin-containing tooth response to drug regulation of cell fate specification embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade skin development response to estrogen canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition canonical Wnt signaling pathway involved in negative regulation of apoptotic process myoblast differentiation bone resorption regulation of cell differentiation negative regulation of cell differentiation positive regulation of endothelial cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic response to cadmium ion chromatin-mediated maintenance of transcription cell maturation synaptic vesicle transport animal organ development thymus development oocyte development embryonic foregut morphogenesis regulation of smooth muscle cell proliferation negative regulation of oligodendrocyte differentiation synapse organization smooth muscle cell differentiation protein heterooligomerization positive regulation of telomerase activity oviduct development canonical Wnt signaling pathway limb development trachea morphogenesis trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development lung induction epithelial cell differentiation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation mesenchymal cell proliferation involved in lung development positive regulation of branching involved in lung morphogenesis endothelial tube morphogenesis fungiform papilla formation canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation sympathetic ganglion development regulation of centromeric sister chromatid cohesion cellular response to mechanical stimulus cellular response to growth factor stimulus cellular response to organic cyclic compound cellular response to indole-3-methanol renal system development renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation regulation of nephron tubule epithelial cell differentiation regulation of calcium ion import negative regulation of neuron death cellular response to insulin-like growth factor stimulus regulation of protein localization to cell surface positive regulation of determination of dorsal identity negative regulation of apoptotic signaling pathway epithelial to mesenchymal transition negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Wnt signaling pathway, calcium modulating pathway response to activity stem cell population maintenance androgen receptor signaling pathway hindbrain development positive regulation of type I interferon production hair cell differentiation catenin import into nucleus proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus regulation of angiogenesis regulation of fibroblast proliferation positive regulation of skeletal muscle tissue development embryonic cranial skeleton morphogenesis regulation of neurogenesis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of muscle cell differentiation positive regulation of histone H3-K4 methylation cranial ganglion development cellular response to lithium ion positive regulation of chromatin-mediated maintenance of transcription regulation of euchromatin binding regulation of core promoter binding beta-catenin-TCF complex assembly beta-catenin destruction complex disassembly midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation embryonic brain development dorsal root ganglion development positive regulation of DNA-templated transcription, initiation
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