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Phospho-c-Met (Tyr1349) Antibody (PA5-97348) in WB
Western blot analysis of Phospho-c-Met (Tyr1349) in extracts of HeLa cells. Samples were incubated with Phospho-c-Met (Tyr1349) Polyclonal antibody (Product # PA5-97348) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. HeLa cells were treated by HGF (40 ng/mL) for 10 minutes after serum-starvation overnight. Lysates/proteins: 25 µg per lan... View More
产品信息
PA5-97348
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphorylated peptide around Y1349 of human MET (NP_0002362)
偶联物
形式
Liquid
浓度
0.75 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2809150
产品详细信息
Positive Samples: HeLa; Cellular Location: Membrane, Single-pass type I membrane protein
Immunogen sequence: EHYVHV
靶标信息
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Met; cMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF receptor; HGF-SF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; oncogene MET; Proto-oncogene c-Met; sc MET; Scatter factor receptor; SF receptor; soluble c met; Tyrosine-protein kinase Met
基因别名: AUTS9; c-Met; DFNB97; HGFR; MET; RCCP2
UniProt ID: (Human) B5A932, (Rat) P97523
Entrez Gene ID: (Human) 4233, (Rat) 24553
protein tyrosine kinase activity
hepatocyte growth factor-activated receptor activity
protein binding
ATP binding
protein phosphatase binding
protein kinase activity
beta-catenin binding
protein complex binding
phospholipase binding
phosphatidylinositol 3-kinase binding
protein heterodimerization activity
endothelial cell morphogenesis
signal transduction
cell surface receptor signaling pathway
cell proliferation
negative regulation of autophagy
peptidyl-tyrosine phosphorylation
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
branching morphogenesis of an epithelial tube
positive chemotaxis
semaphorin-plexin signaling pathway
negative regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of endothelial cell chemotaxis
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
neuron migration
liver development
placenta development
brain development
muscle organ development
skeletal muscle tissue development
cell aging
lactation
male gonad development
response to wounding
response to acidic pH
positive regulation of gene expression
positive regulation of peptidyl-threonine phosphorylation
negative regulation of peptidyl-threonine phosphorylation
positive regulation of glucose transport
positive regulation of neuron projection development
oligodendrocyte development
response to organic cyclic compound
muscle cell migration
myotube differentiation
central nervous system neuron differentiation
sperm motility
adult behavior
pancreas development
positive regulation of peptidyl-serine phosphorylation
response to drug
glucose homeostasis
response to peptide hormone
positive regulation of DNA replication
positive regulation of mitotic nuclear division
protein autophosphorylation
positive regulation of dendrite morphogenesis
modulation of synaptic transmission
myoblast proliferation
excitatory postsynaptic potential
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
cellular response to inorganic substance
cellular response to arsenic-containing substance
cellular response to glucose stimulus
cellular response to interleukin-6
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
