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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • c-Myc Antibodies

          Invitrogen

          Phospho-c-Myc (Ser373) Polyclonal Antibody

          查看其他94个c-Myc抗体

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          Cite Phospho-c-Myc (Ser373) Polyclonal Antibody

          • 抗体检测数据 (2)
          Phospho-c-Myc (Ser373) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Phospho-c-Myc (Ser373) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          图: 1 / 2

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          Phospho-c-Myc (Ser373) Antibody (PA5-37651) in IHC (P)

          Immunohistochemical analysis of Phospho-c-Myc (Ser373) in paraffin-embedded Human breast carcinoma tissue using Phospho-c-Myc (Ser373) Polyclonal Antibody (Product # PA5-37651). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          Phospho-c-Myc (Ser373) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-c-Myc (Ser373) Antibody in Western Blot (WB)
          Phospho-c-Myc (Ser373) Polyclonal Antibody

          产品信息

          PA5-37651

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:1,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50-1:100
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Peptide sequence around phosphorylation site of serine 373 derived from Human Myc.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS, pH 7.4, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2554259

          产品详细信息

          A suggested positive control for Western blot is A431 cells; suggested positive control for IHC is human breast carcinoma.

          靶标信息

          The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          引用该产品

          生物信息学

          蛋白别名: Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; c-myc epitope tag; c-myc proto-oncogene; Class E basic helix-loop-helix protein 39; cmyc; Myc protein; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; myelocytomatosis viral oncogene homolog; Proto-oncogene c-Myc; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog

          查看更多 收起

          基因别名: AU016757; BHLHE39; c-Myc; mMyc; MRTL; MYC; Myc2; MYCC; Niard; Nird; RNCMYC

          查看更多 收起

          UniProt ID: (Human) P01106, (Rat) P09416, (Mouse) P01108

          查看更多 收起

          Entrez Gene ID: (Human) 4609, (Rat) 24577, (Mouse) 17869

          查看更多 收起

          功能
          RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein complex binding protein dimerization activity repressing transcription factor binding E-box binding core promoter proximal region sequence-specific DNA binding double-stranded DNA binding sequence-specific DNA binding protein heterodimerization activity basic helix-loop-helix transcription factor
          参与通路
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade branching involved in ureteric bud morphogenesis positive regulation of mesenchymal cell proliferation energy reserve metabolic process chromatin remodeling transcription from RNA polymerase II promoter cellular iron ion homeostasis cellular response to DNA damage stimulus cell cycle arrest Notch signaling pathway positive regulation of cell proliferation response to gamma radiation regulation of gene expression oxygen transport regulation of telomere maintenance negative regulation of stress-activated MAPK cascade cellular response to UV cellular response to drug response to drug negative regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process fibroblast apoptotic process negative regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation negative regulation of fibroblast proliferation positive regulation of epithelial cell proliferation chromosome organization negative regulation of cell division canonical Wnt signaling pathway response to growth factor positive regulation of metanephric cap mesenchymal cell proliferation beta-catenin-TCF complex assembly positive regulation of DNA biosynthetic process positive regulation of response to DNA damage stimulus in utero embryonic development B cell apoptotic process regulation of oxidative phosphorylation positive regulation of B cell apoptotic process glucose metabolic process transcription, DNA-templated DNA-templated transcription, initiation regulation of transcription, DNA-templated pyruvate transport amino acid transport activation of cysteine-type endopeptidase activity involved in apoptotic process inner mitochondrial membrane organization regulation of mitotic cell cycle cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage glycoprotein metabolic process response to radiation pathogenesis response to wounding flavonoid metabolic process negative regulation of gene expression positive regulation of mitochondrial membrane potential Wnt signaling pathway protein processing transformation of host cell by virus hypothalamus development negative regulation of protein binding response to estradiol skeletal muscle cell differentiation middle ear morphogenesis regulation of apoptotic process positive regulation of catalytic activity response to alkaloid pigmentation canonical Wnt signaling pathway involved in positive regulation of wound healing canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process G0 to G1 transition positive regulation of cell cycle positive regulation of glycolytic process negative regulation of glucose import lactic acid secretion skeletal system morphogenesis detection of mechanical stimulus involved in sensory perception of sound negative regulation of cell death cellular response to carbohydrate stimulus cellular response to interleukin-1 cellular response to estrogen stimulus cellular response to organic cyclic compound cellular response to hydrostatic pressure fungal-type cell wall polysaccharide metabolic process positive regulation of cellular respiration positive regulation of ATP biosynthetic process positive regulation of apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.
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