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Invitrogen
Phospho-p70 S6 Kinase (Thr421) Polyclonal Antibody
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Phospho-p70 S6 Kinase (Thr421) Antibody (PA5-36864) in IHC (P)
Immunohistochemistry analysis of Phospho-p70 S6 Kinase (Thr421) in paraffin-embedded human breast carcinoma tissue (cytoplasmic and nucleus staining) and negative control (right, with PBS only). Samples were incubated with Phospho-p70 S6 Kinase (Thr421) polyclonal antibody (Product # PA5-36864) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
产品信息
PA5-36864
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide derived from human p70 S6K around the phosphorylation site of Threonine 421
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects endogenous protein at a molecular weight of 59, 70 and 85 kDa. It also detects p85 S6 kinase when phosphorylated at Thr444.
Purity is >95% by SDS-PAGE.
靶标信息
RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 70 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-S6K 1; P70S6K; p70S6K-alpha; P70S6K1; p80-S6K 1; p85 p85S6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6 kinase; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A
基因别名: 2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70/85s6k; p70s6k; PS6K; RPS6KB1; S6K; S6K-beta-1; S6K1; STK14A
UniProt ID: (Human) P23443, (Mouse) Q8BSK8, (Rat) P67999
Entrez Gene ID: (Human) 6198, (Mouse) 72508, (Rat) 83840
protein kinase activity
ribosomal protein S6 kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
PDZ domain binding
peptide binding
identical protein binding
protein phosphatase 2A binding
nucleotide binding
protein serine/threonine kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein modifying enzyme
G1/S transition of mitotic cell cycle
behavioral fear response
skeletal muscle contraction
protein phosphorylation
apoptotic process
signal transduction
germ cell development
aging
response to nutrient
long-term memory
response to heat
response to wounding
response to mechanical stimulus
response to toxic substance
response to glucose
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
positive regulation of smooth muscle cell migration
cell migration
TOR signaling
response to lipopolysaccharide
response to insulin
cellular response to hormone stimulus
response to testosterone
response to glucagon
response to tumor necrosis factor
response to drug
negative regulation of apoptotic process
response to leucine
protein kinase B signaling
response to ethanol
positive regulation of translation
positive regulation of mitotic cell cycle
positive regulation of translational initiation
regulation of glucose import
negative regulation of insulin receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of skeletal muscle tissue growth
positive regulation of smooth muscle cell proliferation
response to glucocorticoid
cellular response to growth factor stimulus
cellular response to organic cyclic compound
negative regulation of extrinsic apoptotic signaling pathway
regulation of translation
cell cycle
phosphorylation
cellular response to insulin stimulus
response to organic substance
response to organonitrogen compound
response to organic cyclic compound
response to amino acid
response to peptide hormone
